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References
UTRdb and UTRsite (RELEASE 2010): a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs.
Nucleic Acids Res. 2010; 38 (Database issue): D75-D80.

UTRdb and UTRsite: a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs.
Nucleic Acids Res. 2005 Jan 1; 33 (Database issue): D141-6.

UTRdb and UTRsite: specialized databases of sequences and functional elements of 5' and 3' untranslated regions of eukaryotic mRNAs. Update 2002.
Nucleic Acids Res. 2002 Jan 1; 30 (1): 335-40.

UTRdb and UTRsite: specialized databases of sequences and functional elements of 5' and 3' untranslated regions of eukaryotic mRNAs.
Nucleic Acids Res. 2000 Jan 1; 28 (1): 193-6

Signal Manager :: View

::General Information
ID U0001
Creation Date 30 July 1997
Updating Date 23 September 2009
Standard Name Histone 3'UTR stem-loop structure (HSL3)
UTRSite Pattern
r1={au,ua,gc,cg,gu,ug}
0...1 mmmm p1=ggyyy u hhuh a r1~p1 mm 0...3
Random Expectation 0.0 hits/kb
::Taxonomy
UTR Region 3'
Taxon Range Eukaryota
::Description
Description

Metazoan histone 3'-UTR mRNAs, lacking a polyA tail, contain a highly conserved stem-loop structure with a six base stem and a four base loop (HSL3). This stem-loop structure plays a different role in the nucleus and in the cytoplasm. In the nucleus, it is involved in pre-mRNA processing and nucleocytoplasmic transport, whereas in the cytoplasm it enhances translation efficiency and regulates histone mRNA stability. The trans-acting factor which interacts with the 3'-UTR hai......

Image
::Features
Feature Key HSL3
::Database Cross-references
Link
RFAM: RF00032
::Transcript(s) / Gene(s)
UTR(s)
Description Species Link Ref.
3'UTR in Mus musculus histone 2, H2aa1 (Hist2h2aa1), mRNA Mus musculus UTRef: 3MMUR026879 [U1]
Transcript(s)
Description Species Link Ref.
Mus musculus histone cluster 2, H2aa1 (Hist2h2aa1), mRNA Mus musculus RefSeq: NM_013549 [T1]
Gene(s)
Description Species Link Ref.
histone cluster 2, H2aa1 Mus musculus EntrezGene: 15267 [G1]
::Protein(s)
Binding Protein(s)
Description Species Link Ref.
Stem loop (histone) binding protein Homo sapiens RefSeq: NP_006518 [B1]
three prime histone mRNA exonuclease 1 Homo sapiens RefSeq: NP_699163 [B2]
Interactor(s) of Binding Protein(s)
Description Species Link Ref.
zinc finger protein 473 [ZPF100] Homo sapiens RefSeq: NP_056243 [P1]
::References
ID [1]
Authors Williams A.S. and Marzluff W.F.
Title The sequence of the stem and flanking sequences at the 3'end of histone mRNA are critical determinants for the binding of the stemm-loop binding protein
Citation Nucleic Acid Research vol.23 n.4
Year 1995
ID [2]
Authors Dominski Z, Marzluff WF.
Title Formation of the 3' end of histone mRNA: getting closer to the end.
Citation Gene 2007 Jul 15; 396(2): 373-90
Year 2007
ID [U1]
Authors Williams A.S. and Marzluff W.F.
Title The sequence of the stem and flanking sequences at the 3'end of histone mRNA are critical determinants for the binding of the stemm-loop binding protein
Citation Nucleic Acid Research vol.23 n.4
Year 1995
ID [T1]
Authors Williams A.S. and Marzluff W.F.
Title The sequence of the stem and flanking sequences at the 3'end of histone mRNA are critical determinants for the binding of the stemm-loop binding protein
Citation Nucleic Acid Research vol.23 n.4
Year 1995
ID [G1]
Authors Williams A.S. and Marzluff W.F.
Title The sequence of the stem and flanking sequences at the 3'end of histone mRNA are critical determinants for the binding of the stemm-loop binding protein
Citation Nucleic Acid Research vol.23 n.4
Year 1995
ID [B1]
Authors Martin F, Schaller A, Eglite S, Schümperli D, Müller B.
Title The gene for histone RNA hairpin binding protein is located on human chromosome 4 and encodes a novel type of RNA binding protein.
Citation EMBO J. 1997 Feb 17; 16(4): 769-78
Year 1997
ID [B2]
Authors Dominski Z, Yang XC, Kaygun H, Dadlez M, Marzluff WF.
Title A 3' exonuclease that specifically interacts with the 3' end of histone mRNA.
Citation Mol. Cell 2003 Aug; 12(2): 295-305
Year 2003
ID [P1]
Authors Dominski Z, Marzluff WF.
Title Formation of the 3' end of histone mRNA: getting closer to the end.
Citation Gene 2007 Jul 15; 396(2): 373-90
Year 2007
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