| ID |
U0001 |
|
| Creation Date |
30 July 1997 |
| Updating Date |
23 September 2009 |
|
| Standard Name |
Histone 3'UTR stem-loop structure (HSL3) |
| UTRSite Pattern |
r1={au,ua,gc,cg,gu,ug}
0...1 mmmm p1=ggyyy u hhuh a r1~p1 mm 0...3
|
| Random Expectation |
0.0 hits/kb |
|
| UTR Region |
3' |
| Taxon Range |
Eukaryota |
|
| Description |
Metazoan histone 3'-UTR mRNAs, lacking a polyA tail,
contain a highly conserved stem-loop structure with a
six base stem and a four base loop (HSL3). This stem-loop
structure plays a different role in the nucleus and in
the cytoplasm. In the nucleus, it is involved in pre-mRNA
processing and nucleocytoplasmic transport, whereas in the
cytoplasm it enhances translation efficiency and regulates
histone mRNA stability. The trans-acting factor which
interacts with the 3'-UTR hai...... |
|
|
| Image |
 |
|
| Feature Key |
HSL3 |
|
| Link |
|
|
| UTR(s) |
| Description |
Species |
Link |
Ref. |
| 3'UTR in Mus musculus histone 2, H2aa1 (Hist2h2aa1), mRNA |
Mus musculus |
UTRef: 3MMUR026879 |
[U1] |
|
| Transcript(s) |
| Description |
Species |
Link |
Ref. |
| Mus musculus histone cluster 2, H2aa1 (Hist2h2aa1), mRNA |
Mus musculus |
RefSeq: NM_013549 |
[T1] |
|
| Gene(s) |
|
|
| Binding Protein(s) |
|
| Interactor(s) of Binding Protein(s) |
|
|
| ID |
[1] |
| Authors |
Williams A.S. and Marzluff W.F. |
| Title |
The sequence of the stem and flanking sequences at the 3'end of histone mRNA are critical determinants for the binding of the stemm-loop binding protein |
| Citation |
Nucleic Acid Research vol.23 n.4 |
| Year |
1995 |
| ID |
[2] |
| Authors |
Dominski Z, Marzluff WF. |
| Title |
Formation of the 3' end of histone mRNA: getting closer to the end. |
| Citation |
Gene 2007 Jul 15; 396(2): 373-90 |
| Year |
2007 |
| ID |
[U1] |
| Authors |
Williams A.S. and Marzluff W.F. |
| Title |
The sequence of the stem and flanking sequences at the 3'end of histone mRNA are critical determinants for the binding of the stemm-loop binding protein |
| Citation |
Nucleic Acid Research vol.23 n.4 |
| Year |
1995 |
| ID |
[T1] |
| Authors |
Williams A.S. and Marzluff W.F. |
| Title |
The sequence of the stem and flanking sequences at the 3'end of histone mRNA are critical determinants for the binding of the stemm-loop binding protein |
| Citation |
Nucleic Acid Research vol.23 n.4 |
| Year |
1995 |
| ID |
[G1] |
| Authors |
Williams A.S. and Marzluff W.F. |
| Title |
The sequence of the stem and flanking sequences at the 3'end of histone mRNA are critical determinants for the binding of the stemm-loop binding protein |
| Citation |
Nucleic Acid Research vol.23 n.4 |
| Year |
1995 |
| ID |
[B1] |
| Authors |
Martin F, Schaller A, Eglite S, Schümperli D, Müller B. |
| Title |
The gene for histone RNA hairpin binding protein is located on human chromosome 4 and encodes a novel type of RNA binding protein. |
| Citation |
EMBO J. 1997 Feb 17; 16(4): 769-78 |
| Year |
1997 |
| ID |
[B2] |
| Authors |
Dominski Z, Yang XC, Kaygun H, Dadlez M, Marzluff WF. |
| Title |
A 3' exonuclease that specifically interacts with the 3' end of histone mRNA. |
| Citation |
Mol. Cell 2003 Aug; 12(2): 295-305 |
| Year |
2003 |
| ID |
[P1] |
| Authors |
Dominski Z, Marzluff WF. |
| Title |
Formation of the 3' end of histone mRNA: getting closer to the end. |
| Citation |
Gene 2007 Jul 15; 396(2): 373-90 |
| Year |
2007 |
