ID
U0001
Creation Date
30 July 1997
Updating Date
23 September 2009
Standard Name
Histone 3'UTR stem-loop structure (HSL3)
UTRSite Pattern
r1={au,ua,gc,cg,gu,ug}
0...1 mmmm p1=ggyyy u hhuh a r1~p1 mm 0...3
Random Expectation
0.0 hits/kb
UTR Region
3'
Taxon Range
Eukaryota
Description
Metazoan histone 3'-UTR mRNAs, lacking a polyA tail,
contain a highly conserved stem-loop structure with a
six base stem and a four base loop (HSL3). This stem-loop
structure plays a different role in the nucleus and in
the cytoplasm. In the nucleus, it is involved in pre-mRNA
processing and nucleocytoplasmic transport, whereas in the
cytoplasm it enhances translation efficiency and regulates
histone mRNA stability. The trans-acting factor which
interacts with the 3'-UTR hai......
Image
Feature Key
HSL3
Link
UTR(s)
Description
Species
Link
Ref.
3'UTR in Mus musculus histone 2, H2aa1 (Hist2h2aa1), mRNA
Mus musculus
UTRef: 3MMUR026879
[U1]
Transcript(s)
Description
Species
Link
Ref.
Mus musculus histone cluster 2, H2aa1 (Hist2h2aa1), mRNA
Mus musculus
RefSeq: NM_013549
[T1]
Gene(s)
Binding Protein(s)
Interactor(s) of Binding Protein(s)
ID
Authors
Williams A.S. and Marzluff W.F.
Title
The sequence of the stem and flanking sequences at the 3'end of histone mRNA are critical determinants for the binding of the stemm-loop binding protein
Citation
Nucleic Acid Research vol.23 n.4
Year
1995
ID
[2]
Authors
Dominski Z, Marzluff WF.
Title
Formation of the 3' end of histone mRNA: getting closer to the end.
Citation
Gene 2007 Jul 15; 396(2): 373-90
Year
2007
ID
Authors
Williams A.S. and Marzluff W.F.
Title
The sequence of the stem and flanking sequences at the 3'end of histone mRNA are critical determinants for the binding of the stemm-loop binding protein
Citation
Nucleic Acid Research vol.23 n.4
Year
1995
ID
Authors
Williams A.S. and Marzluff W.F.
Title
The sequence of the stem and flanking sequences at the 3'end of histone mRNA are critical determinants for the binding of the stemm-loop binding protein
Citation
Nucleic Acid Research vol.23 n.4
Year
1995
ID
Authors
Williams A.S. and Marzluff W.F.
Title
The sequence of the stem and flanking sequences at the 3'end of histone mRNA are critical determinants for the binding of the stemm-loop binding protein
Citation
Nucleic Acid Research vol.23 n.4
Year
1995
ID
[B1]
Authors
Martin F, Schaller A, Eglite S, Schümperli D, Müller B.
Title
The gene for histone RNA hairpin binding protein is located on human chromosome 4 and encodes a novel type of RNA binding protein.
Citation
EMBO J. 1997 Feb 17; 16(4): 769-78
Year
1997
ID
[B2]
Authors
Dominski Z, Yang XC, Kaygun H, Dadlez M, Marzluff WF.
Title
A 3' exonuclease that specifically interacts with the 3' end of histone mRNA.
Citation
Mol. Cell 2003 Aug; 12(2): 295-305
Year
2003
ID
[P1]
Authors
Dominski Z, Marzluff WF.
Title
Formation of the 3' end of histone mRNA: getting closer to the end.
Citation
Gene 2007 Jul 15; 396(2): 373-90
Year
2007
