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::General Information
ID U0002
Creation Date 30 July 1997
Updating Date 28 September 2009
Standard Name Iron Responsive Element (IRE)
UTRSite Pattern
r1={au,ua,gc,cg,gu,ug}
(p1=2...8 c p2=5...5 CAGWGH r1~p2 r1~p1 | 
p3=2...8 nnc p4=5...5 CAGWGH r1~p4 n r1~p3 |
p5=6...8 c p6=2...2 p7=3...3 CAGWGH r1~p7 u r1~p6 r1~p5 )
Random Expectation 0.0005537610 hits/kb
::Taxonomy
UTR Region All
Taxon Range Metazoa
::Description
Description

The "iron-responsive element" (IRE) is a particular hairpin structure located in the 5'-untranslated region (5'-UTR) or in the 3'-untranslated region (3'-UTR) of various mRNAs coding for proteins involved in cellular iron metabolism. The IREs are recognized by trans-acting proteins known as Iron Regulatory Proteins (IRPs) that control mRNA translation rate and stability. Two closely related IRPs, denoted as IRP-1 and IRP-2, have been identified so far which bind IREs and become inactiv......

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::Features
Feature Key IRE
::Database Cross-references
Link
RFAM: RF00037
::Transcript(s) / Gene(s)
UTR(s)
Description Species Link Ref.
5'UTR in Homo sapiens ferritin, heavy polypeptide 1 (FTH1), mRNA. Homo sapiens UTRef: 5HSAR020849 [U1][U2]
3'UTR in Homo sapiens transferrin receptor (p90, CD71) (TFRC), mRNA. Homo sapiens UTRef: 3HSAR032186 [U3][U4]
Transcript(s)
Description Species Link Ref.
Homo sapiens ferritin, heavy polypeptide 1 (FTH1), mRNA. Homo sapiens RefSeq: NM_002032
Homo sapiens transferrin receptor (p90, CD71) (TFRC), mRNA Homo sapiens RefSeq: NM_003234
Gene(s)
Description Species Link Ref.
Ferritin H subunit (FTH1) Homo sapiens ENSEMBL: ENSG00000167996
Transferrin receptor protein 1 (TfR1, TR, TfR, Trfr, CD71 antigen, T9, p90) Homo sapiens ENSEMBL: ENSG00000072274
::Protein(s)
Binding Protein(s)
Description Species Link Ref.
Iron-responsive element-binding protein 1 Homo sapiens UniProt: P21399 [B1]
Iron-responsive element-binding protein 2 Homo sapiens UniProt: P48200 [B2]
::References
ID [1]
Authors Hentze M.W. and Kuhn L.C.
Title Molecular control of vertebrate iron metabolism: mRNA based regulatory circuits operated by iron, nitric oxide, and oxidative stress
Citation Proc. Natl. Acad. Sci. USA 93: 8175-8182
Year 1996
ID [2]
Authors Sanchez M, Galy B, Dandekar T, Bengert P, Vainshtein Y, Stollte J Muckenthaler MU, Hentze MW.
Title Iron regulation and the cell cycle: Identification of an iron-responsive element in the 3' untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy.
Citation J Biol Chem. 2006
Year 2006
ID [3]
Authors Gunshin H, Allerson CR, Polycarpou-Schwarz M, Rofts A, Rogers JT, Kishi F, Hentze MW, Rouault TA, Andrews NC, Hediger MA.
Title Iron-dependent regulation of the divalent metal ion transporter.
Citation FEBS Lett. 2001 Dec 7; 509(2): 309-16
Year 2001
ID [U1]
Authors Hentze M.W. and Kuhn L.C.
Title Molecular control of vertebrate iron metabolism: mRNA based regulatory circuits operated by iron, nitric oxide, and oxidative stress
Citation Proc. Natl. Acad. Sci. USA 93: 8175-8182
Year 1996
ID [U2]
Authors Hentze MW, Muckenthaler MU, Andrews NC.
Title Balancing acts: molecular control of mammalian iron metabolism.
Citation Cell 2004 Apr 30; 117(3): 285-97
Year 2004
ID [U3]
Authors Hentze M.W. and Kuhn L.C.
Title Molecular control of vertebrate iron metabolism: mRNA based regulatory circuits operated by iron, nitric oxide, and oxidative stress
Citation Proc. Natl. Acad. Sci. USA 93: 8175-8182
Year 1996
ID [U4]
Authors Hentze MW, Muckenthaler MU, Andrews NC.
Title Balancing acts: molecular control of mammalian iron metabolism.
Citation Cell 2004 Apr 30; 117(3): 285-97
Year 2004
ID [B1]
Authors Hentze MW, Muckenthaler MU, Andrews NC.
Title Balancing acts: molecular control of mammalian iron metabolism.
Citation Cell 2004 Apr 30; 117(3): 285-97
Year 2004
ID [B2]
Authors Hentze MW, Muckenthaler MU, Andrews NC.
Title Balancing acts: molecular control of mammalian iron metabolism.
Citation Cell 2004 Apr 30; 117(3): 285-97
Year 2004