| ID |
U0002 |
|
| Creation Date |
30 July 1997 |
| Updating Date |
28 September 2009 |
|
| Standard Name |
Iron Responsive Element (IRE) |
| UTRSite Pattern |
r1={au,ua,gc,cg,gu,ug}
(p1=2...8 c p2=5...5 CAGWGH r1~p2 r1~p1 |
p3=2...8 nnc p4=5...5 CAGWGH r1~p4 n r1~p3 |
p5=6...8 c p6=2...2 p7=3...3 CAGWGH r1~p7 u r1~p6 r1~p5 )
|
| Random Expectation |
0.0005537610 hits/kb |
|
| UTR Region |
All |
| Taxon Range |
Metazoa |
|
| Description |
The "iron-responsive element" (IRE) is a particular hairpin structure located in the 5'-untranslated region (5'-UTR) or in the 3'-untranslated region (3'-UTR) of various mRNAs coding for proteins involved in cellular iron metabolism. The IREs are recognized by trans-acting proteins known as Iron Regulatory Proteins (IRPs) that control mRNA translation rate and stability. Two closely related IRPs, denoted as IRP-1 and IRP-2, have been identified so far which bind IREs and become inactiv...... |
|
|
| Image |
 |
|
| Feature Key |
IRE |
|
| Link |
|
|
| UTR(s) |
|
| Transcript(s) |
| Description |
Species |
Link |
Ref. |
| Homo sapiens ferritin, heavy polypeptide 1 (FTH1), mRNA. |
Homo sapiens |
RefSeq: NM_002032 |
|
| Homo sapiens transferrin receptor (p90, CD71) (TFRC), mRNA |
Homo sapiens |
RefSeq: NM_003234 |
|
|
| Gene(s) |
|
|
| Binding Protein(s) |
|
|
| ID |
[1] |
| Authors |
Hentze M.W. and Kuhn L.C. |
| Title |
Molecular control of vertebrate iron metabolism: mRNA based regulatory circuits operated by iron, nitric oxide, and oxidative stress |
| Citation |
Proc. Natl. Acad. Sci. USA 93: 8175-8182 |
| Year |
1996 |
| ID |
[2] |
| Authors |
Sanchez M, Galy B, Dandekar T, Bengert P, Vainshtein Y, Stollte J Muckenthaler MU, Hentze MW. |
| Title |
Iron regulation and the cell cycle: Identification of an iron-responsive element in the 3' untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy. |
| Citation |
J Biol Chem. 2006 |
| Year |
2006 |
| ID |
[3] |
| Authors |
Gunshin H, Allerson CR, Polycarpou-Schwarz M, Rofts A, Rogers JT, Kishi F, Hentze MW, Rouault TA, Andrews NC, Hediger MA. |
| Title |
Iron-dependent regulation of the divalent metal ion transporter. |
| Citation |
FEBS Lett. 2001 Dec 7; 509(2): 309-16 |
| Year |
2001 |
| ID |
[U1] |
| Authors |
Hentze M.W. and Kuhn L.C. |
| Title |
Molecular control of vertebrate iron metabolism: mRNA based regulatory circuits operated by iron, nitric oxide, and oxidative stress |
| Citation |
Proc. Natl. Acad. Sci. USA 93: 8175-8182 |
| Year |
1996 |
| ID |
[U2] |
| Authors |
Hentze MW, Muckenthaler MU, Andrews NC. |
| Title |
Balancing acts: molecular control of mammalian iron metabolism. |
| Citation |
Cell 2004 Apr 30; 117(3): 285-97 |
| Year |
2004 |
| ID |
[U3] |
| Authors |
Hentze M.W. and Kuhn L.C. |
| Title |
Molecular control of vertebrate iron metabolism: mRNA based regulatory circuits operated by iron, nitric oxide, and oxidative stress |
| Citation |
Proc. Natl. Acad. Sci. USA 93: 8175-8182 |
| Year |
1996 |
| ID |
[U4] |
| Authors |
Hentze MW, Muckenthaler MU, Andrews NC. |
| Title |
Balancing acts: molecular control of mammalian iron metabolism. |
| Citation |
Cell 2004 Apr 30; 117(3): 285-97 |
| Year |
2004 |
| ID |
[B1] |
| Authors |
Hentze MW, Muckenthaler MU, Andrews NC. |
| Title |
Balancing acts: molecular control of mammalian iron metabolism. |
| Citation |
Cell 2004 Apr 30; 117(3): 285-97 |
| Year |
2004 |
| ID |
[B2] |
| Authors |
Hentze MW, Muckenthaler MU, Andrews NC. |
| Title |
Balancing acts: molecular control of mammalian iron metabolism. |
| Citation |
Cell 2004 Apr 30; 117(3): 285-97 |
| Year |
2004 |
