ID
U0002
Creation Date
30 July 1997
Updating Date
28 September 2009
Standard Name
Iron Responsive Element (IRE)
UTRSite Pattern
r1={au,ua,gc,cg,gu,ug}
(p1=2...8 c p2=5...5 CAGWGH r1~p2 r1~p1 |
p3=2...8 nnc p4=5...5 CAGWGH r1~p4 n r1~p3 |
p5=6...8 c p6=2...2 p7=3...3 CAGWGH r1~p7 u r1~p6 r1~p5 )
Random Expectation
0.0005537610 hits/kb
UTR Region
All
Taxon Range
Metazoa
Description
The "iron-responsive element" (IRE) is a particular hairpin structure located in the 5'-untranslated region (5'-UTR) or in the 3'-untranslated region (3'-UTR) of various mRNAs coding for proteins involved in cellular iron metabolism. The IREs are recognized by trans-acting proteins known as Iron Regulatory Proteins (IRPs) that control mRNA translation rate and stability. Two closely related IRPs, denoted as IRP-1 and IRP-2, have been identified so far which bind IREs and become inactiv......
Image
Feature Key
IRE
Link
UTR(s)
Transcript(s)
Description
Species
Link
Ref.
Homo sapiens ferritin, heavy polypeptide 1 (FTH1), mRNA.
Homo sapiens
RefSeq: NM_002032
Homo sapiens transferrin receptor (p90, CD71) (TFRC), mRNA
Homo sapiens
RefSeq: NM_003234
Gene(s)
Binding Protein(s)
ID
[1]
Authors
Hentze M.W. and Kuhn L.C.
Title
Molecular control of vertebrate iron metabolism: mRNA based regulatory circuits operated by iron, nitric oxide, and oxidative stress
Citation
Proc. Natl. Acad. Sci. USA 93: 8175-8182
Year
1996
ID
[2]
Authors
Sanchez M, Galy B, Dandekar T, Bengert P, Vainshtein Y, Stollte J Muckenthaler MU, Hentze MW.
Title
Iron regulation and the cell cycle: Identification of an iron-responsive element in the 3' untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy.
Citation
J Biol Chem. 2006
Year
2006
ID
[3]
Authors
Gunshin H, Allerson CR, Polycarpou-Schwarz M, Rofts A, Rogers JT, Kishi F, Hentze MW, Rouault TA, Andrews NC, Hediger MA.
Title
Iron-dependent regulation of the divalent metal ion transporter.
Citation
FEBS Lett. 2001 Dec 7; 509(2): 309-16
Year
2001
ID
[U1]
Authors
Hentze M.W. and Kuhn L.C.
Title
Molecular control of vertebrate iron metabolism: mRNA based regulatory circuits operated by iron, nitric oxide, and oxidative stress
Citation
Proc. Natl. Acad. Sci. USA 93: 8175-8182
Year
1996
ID
[U2]
Authors
Hentze MW, Muckenthaler MU, Andrews NC.
Title
Balancing acts: molecular control of mammalian iron metabolism.
Citation
Cell 2004 Apr 30; 117(3): 285-97
Year
2004
ID
[U3]
Authors
Hentze M.W. and Kuhn L.C.
Title
Molecular control of vertebrate iron metabolism: mRNA based regulatory circuits operated by iron, nitric oxide, and oxidative stress
Citation
Proc. Natl. Acad. Sci. USA 93: 8175-8182
Year
1996
ID
[U4]
Authors
Hentze MW, Muckenthaler MU, Andrews NC.
Title
Balancing acts: molecular control of mammalian iron metabolism.
Citation
Cell 2004 Apr 30; 117(3): 285-97
Year
2004
ID
[B1]
Authors
Hentze MW, Muckenthaler MU, Andrews NC.
Title
Balancing acts: molecular control of mammalian iron metabolism.
Citation
Cell 2004 Apr 30; 117(3): 285-97
Year
2004
ID
[B2]
Authors
Hentze MW, Muckenthaler MU, Andrews NC.
Title
Balancing acts: molecular control of mammalian iron metabolism.
Citation
Cell 2004 Apr 30; 117(3): 285-97
Year
2004
