| ID |
U0003 |
|
| Creation Date |
30 July 1997 |
| Updating Date |
28 September 2009 |
|
| Standard Name |
Selenocysteine Insertion Sequence - type 1 (SECIS1) |
| UTRSite Pattern |
(R1={AU,UA,GC,CG,GU,UG}
P1=4...19 2...9 R UGAN
P2=8...12 0...3 AAV 7...10 R1~P2[1,0,0]
P2:(((^RR | ^MC) | ^SU) 6...10 )
NGAN 2...9 R1~P1
|
P3=4...19 P10=2...9 A UGAN
P4=8...12 P4:(((^RR | ^MC) | ^SU) 6...10 )
0...3 AAV P5=11...14 P5:(0...1 P6=2...7 3...6 R1~P6 0...3$)
(((R1~P4[1,0,0] | R1~P4[1,1,0]) | R1~P4[1,0,1]) | R1~P4[0,1,1])
NGAN 2...9 R1~P3
)
|
| Random Expectation |
0.0 hits/kb |
|
| UTR Region |
3' |
| Taxon Range |
Metazoa |
|
| Description |
Specific incorporation of selenocysteine in selenoproteins is directed
by UGA codons residing within the coding sequence of the corresponding mRNAs.
Translation of UGA, usually a termination codon, as selenocysteine requires
a conserved stem-loop structure called |
|
|
| Image |
 |
|
| Feature Key |
SECIS1 |
|
| Link |
|
|
| UTR(s) |
| Description |
Species |
Link |
Ref. |
| deiodinase, iodothyronine, type I (SECIS type 1) |
Homo sapiens |
UTRef: 3HSAR026663 |
|
| selenophosphate synthetase 2 (SECIS type 2) |
Homo sapiens |
UTRef: 3HSAR017444 |
|
|
| Transcript(s) |
|
| Gene(s) |
|
|
| Binding Protein(s) |
|
| Interactor(s) of Binding Protein(s) |
| Description |
Species |
Link |
Ref. |
| eukaryotic elongation factor, selenocysteine-tRNA-specific (EEFSEC) |
Homo sapiens |
UniProt: P57772 |
|
|
|
| ID |
[1] |
| Authors |
Walczak R., Westhof E., Carbon P. and Krol A. |
| Title |
A novel RNA structural motif in the selenocysteine insertion element of eukaryotic selenoprotein mRNAs |
| Citation |
RNA 2: 367-379 |
| Year |
1996 |
| ID |
[2] |
| Authors |
Walczak R., Carbon P. and Krol A. |
| Title |
An essential non-Watson-Crick base pair motif in 3' UTR to mediate selenoprotein translation |
| Citation |
RNA 4, 74-84 |
| Year |
1998 |
| ID |
[3] |
| Authors |
Fagegaltier D, Lescure A, Walczak R, Carbon P, Krol A. |
| Title |
Structural analysis of new local features in SECIS RNA hairpins |
| Citation |
Nucleic Acids Res. 28, 2679-89 |
| Year |
2000 |
| ID |
[4] |
| Authors |
Korotkov KV, Novoselov SV, Hatfield DL, Gladyshev VN. |
| Title |
Mammalian selenoprotein in which selenocysteine (Sec) incorporation is supported by a new form of Sec insertion sequence element. |
| Citation |
Mol Cell Biol. 22(5):1402-11 |
| Year |
2002 |
| ID |
[5] |
| Authors |
Novoselov SV, Rao M, Onoshko NV, Zhi H, Kryukov GV, Xiang Y, Weeks DP, Hatfield DL, Gladyshev VN. |
| Title |
Selenoproteins and selenocysteine insertion system in the model plant cell system, Chlamydomonas reinhardtii. |
| Citation |
EMBO J. 21(14):3681-93. |
| Year |
2002 |
| ID |
[6] |
| Authors |
Copeland PR, Fletcher JE, Carlson BA, Hatfield DL, Driscoll DM. |
| Title |
A novel RNA binding protein, SBP2, is required for the translation of mammalian selenoprotein mRNAs. |
| Citation |
EMBO J. 19(2):306-14. |
| Year |
2000 |
| ID |
[7] |
| Authors |
Lescure A, Fagegaltier D, Carbon P, Krol A. |
| Title |
Protein factors mediating selenoprotein synthesis. |
| Citation |
Curr Protein Pept Sci. 3(1):143-51. |
| Year |
2002 |
| ID |
[8] |
| Authors |
Allmang C, Carbon P, Krol A. |
| Title |
The SBP2 and 15.5 kD/Snu13p proteins share the same RNA binding domain: identification of SBP2 amino acids important to SECIS RNA binding.
|
| Citation |
RNA. 2002 8(10):1308-18. |
| Year |
2002 |
| ID |
[9] |
| Authors |
Chavatte L, Brown BA, Driscoll DM. |
| Title |
Ribosomal protein L30 is a component of the UGA-selenocysteine recoding machinery in eukaryotes.
|
| Citation |
Nat Struct Mol Biol. 2005 12(5):408-16. . |
| Year |
2005 |
| ID |
[10] |
| Authors |
Lescure A, Allmang C, Yamada K, Carbon P, Krol A. |
| Title |
cDNA cloning, expression pattern and RNA binding analysis of human selenocysteine insertion sequence (SECIS) binding protein 2.
|
| Citation |
Gene. 2002 291(1-2):279-85. |
| Year |
2002 |
| ID |
[11] |
| Authors |
Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigo R, Gladyshev VN. |
| Title |
Characterization of mammalian selenoproteomes.
|
| Citation |
Science. 300(5624):1439-43. |
| Year |
2003 |
| ID |
[12] |
| Authors |
Tujebajeva RM, Copeland PR, Xu XM, Carlson BA, Harney JW, Driscoll DM, Hatfield DL, Berry MJ. |
| Title |
Decoding apparatus for eukaryotic selenocysteine insertion. |
| Citation |
EMBO Rep. 1(2):158-63. |
| Year |
2000 |
| ID |
[13] |
| Authors |
Grundner-Culemann E, Martin GW 3rd, Harney JW, Berry MJ. |
| Title |
Two distinct SECIS structures capable of directing selenocysteine incorporation in eukaryotes.
|
| Citation |
RNA. 5(5):625-35. |
| Year |
1999 |
| ID |
[T1] |
| Authors |
Walczak R., Westhof E., Carbon P. and Krol A. |
| Title |
A novel RNA structural motif in the selenocysteine insertion element of eukaryotic selenoprotein mRNAs |
| Citation |
RNA 2: 367-379 |
| Year |
1996 |
| ID |
[T2] |
| Authors |
Walczak R., Carbon P. and Krol A. |
| Title |
An essential non-Watson-Crick base pair motif in 3' UTR to mediate selenoprotein translation |
| Citation |
RNA 4, 74-84 |
| Year |
1998 |
| ID |
[T3] |
| Authors |
Walczak R., Westhof E., Carbon P. and Krol A. |
| Title |
A novel RNA structural motif in the selenocysteine insertion element of eukaryotic selenoprotein mRNAs |
| Citation |
RNA 2: 367-379 |
| Year |
1996 |
| ID |
[T4] |
| Authors |
Walczak R., Carbon P. and Krol A. |
| Title |
An essential non-Watson-Crick base pair motif in 3' UTR to mediate selenoprotein translation |
| Citation |
RNA 4, 74-84 |
| Year |
1998 |
