| ID |
U0004 |
|
| Creation Date |
30 July 1997 |
| Updating Date |
10 August 2006 |
|
| Standard Name |
Selenocysteine Insertion Sequence - type 2 (SECIS2) |
| UTRSite Pattern |
r1={au,ua,gc,cg,gu,ug}
p1=4...19
p2=2...9 a
ugan
p3=8...12 p3:(((^rr | ^mc) | ^su) 6...10 )
p4=0...3 p5=aav p6=11...14 p6:(0...1 p7=2...7 3...6 r1~p7 0...3$)
(((r1~p3[1,0,0] | r1~p3[1,1,0]) | r1~p3[1,0,1]) | r1~p3[0,1,1])
ngan
p10=2...9
r1~p1
|
| Random Expectation |
0.0 hits/kb |
|
| UTR Region |
3' |
| Taxon Range |
Metazoa |
|
| Description |
Specific incorporation of selenocysteine in selenoproteins is directed
by UGA codons residing within the coding sequence of the corresponding mRNAs.
Translation of UGA, usually a termination codon, as selenocysteine requires
a conserved stem-loop structure called |
|
|
| Image |
 |
|
| Feature Key |
SECIS2 |
|
| Link |
|
|
| UTR(s) |
| Description |
Species |
Link |
Ref. |
| 3'UTR in Homo sapiens deiodinase, iodothyronine, type II (DIO2), transcript variant 1, mRNA. |
Homo sapiens |
UTRef: 3HSAR026618 |
|
|
| Transcript(s) |
| Description |
Species |
Link |
Ref. |
| Homo sapiens deiodinase, iodothyronine, type II (DIO2), transcript variant 1, mRNA. |
Homo sapiens |
RefSeq: NM_013989 |
|
|
| Gene(s) |
| Description |
Species |
Link |
Ref. |
| Type II iodothyronine deiodinase (EC 1.97.1.10) (Type-II 5'deiodinase) (DIOII) (Type 2 DI) (5DII) |
Homo sapiens |
ENSEMBL: ENSG00000211448 |
|
|
|
| Binding Protein(s) |
|
| Interactor(s) of Binding Protein(s) |
| Description |
Species |
Link |
Ref. |
| eukaryotic elongation factor, selenocysteine-tRNA-specific (EEFSEC) |
Homo sapiens |
UniProt: P57772 |
|
|
|
| ID |
[1] |
| Authors |
Walczak R., Westhof E., Carbon P. and Krol A. |
| Title |
A novel RNA structural motif in the selenocysteine insertion element of eukaryotic selenoprotein mRNAs |
| Citation |
RNA 2: 367-379 |
| Year |
1996 |
| ID |
[2] |
| Authors |
Walczak R., Carbon P. and Krol A. |
| Title |
An essential non-Watson-Crick base pair motif in 3' UTR to mediate selenoprotein translation |
| Citation |
RNA 4, 74-84 |
| Year |
1998 |
| ID |
[3] |
| Authors |
Fagegaltier D, Lescure A, Walczak R, Carbon P, Krol A. |
| Title |
Structural analysis of new local features in SECIS RNA hairpins |
| Citation |
Nucleic Acids Res. 28, 2679-89 |
| Year |
2000 |
| ID |
[4] |
| Authors |
Korotkov KV, Novoselov SV, Hatfield DL, Gladyshev VN. |
| Title |
Mammalian selenoprotein in which selenocysteine (Sec) incorporation is supported by a new form of Sec insertion sequence element. |
| Citation |
Mol Cell Biol. 22(5):1402-11 |
| Year |
2002 |
| ID |
[5] |
| Authors |
Novoselov SV, Rao M, Onoshko NV, Zhi H, Kryukov GV, Xiang Y, Weeks DP, Hatfield DL, Gladyshev VN. |
| Title |
Selenoproteins and selenocysteine insertion system in the model plant cell system, Chlamydomonas reinhardtii. |
| Citation |
EMBO J. 21(14):3681-93. |
| Year |
2002 |
| ID |
[6] |
| Authors |
Copeland PR, Fletcher JE, Carlson BA, Hatfield DL, Driscoll DM. |
| Title |
A novel RNA binding protein, SBP2, is required for the translation of mammalian selenoprotein mRNAs. |
| Citation |
EMBO J. 19(2):306-14. |
| Year |
2000 |
| ID |
[7] |
| Authors |
Lescure A, Fagegaltier D, Carbon P, Krol A. |
| Title |
Protein factors mediating selenoprotein synthesis. |
| Citation |
Curr Protein Pept Sci. 3(1):143-51. |
| Year |
2002 |
| ID |
[8] |
| Authors |
Allmang C, Carbon P, Krol A. |
| Title |
The SBP2 and 15.5 kD/Snu13p proteins share the same RNA binding domain: identification of SBP2 amino acids important to SECIS RNA binding.
|
| Citation |
RNA. 2002 8(10):1308-18. |
| Year |
2002 |
| ID |
[9] |
| Authors |
Chavatte L, Brown BA, Driscoll DM. |
| Title |
Ribosomal protein L30 is a component of the UGA-selenocysteine recoding machinery in eukaryotes.
|
| Citation |
Nat Struct Mol Biol. 2005 12(5):408-16. . |
| Year |
2005 |
| ID |
[10] |
| Authors |
Lescure A, Allmang C, Yamada K, Carbon P, Krol A. |
| Title |
cDNA cloning, expression pattern and RNA binding analysis of human selenocysteine insertion sequence (SECIS) binding protein 2.
|
| Citation |
Gene. 2002 291(1-2):279-85. |
| Year |
2002 |
| ID |
[11] |
| Authors |
Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigo R, Gladyshev VN. |
| Title |
Characterization of mammalian selenoproteomes.
|
| Citation |
Science. 300(5624):1439-43. |
| Year |
2003 |
| ID |
[12] |
| Authors |
Tujebajeva RM, Copeland PR, Xu XM, Carlson BA, Harney JW, Driscoll DM, Hatfield DL, Berry MJ. |
| Title |
Decoding apparatus for eukaryotic selenocysteine insertion. |
| Citation |
EMBO Rep. 1(2):158-63. |
| Year |
2000 |
| ID |
[13] |
| Authors |
Grundner-Culemann E, Martin GW 3rd, Harney JW, Berry MJ. |
| Title |
Two distinct SECIS structures capable of directing selenocysteine incorporation in eukaryotes.
|
| Citation |
RNA. 5(5):625-35. |
| Year |
1999 |
