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ID U0006
Creation Date 30 September 1997
Updating Date 30 September 1997
Standard Name Cytoplasmic polyadenylation element (CPE)
UTRSite Pattern
uuuuuwau 1...200 aauaaa 1...100 $
Random Expectation 0.0 hits/kb
UTR Region 3'
Taxon Range Metazoa
Description Cytoplasmic polyadenylation is an evolutionarily conserved mechanism regulating translational activation of a set of quiescent maternal messenger RNAs (mRNAs) during early development. Cytoplasmic poly(A) elongation occurs in a wide range of species, ranging from clam to mouse. The relevance of this process during late oogenesis and early embryogenesis has been shown by studies in the mouse, Xenopus, and Drosophila. In mouse and Xenopus, the only vertebrates so far examined, the critical regulatory sequences, referred to as Cytoplasmic Polyadenylation Elements (CPEs), are AU-rich and located in the 3' untranslated region (3'-UTR) near the canonical nuclear polyadenylation element (AAUAAA), which also is required for proper poly(A) addition. The CPE has the general structure of UUUUUUAU. However, the CPE is not identical in all mRNAs and its position varies relative to AAUAAA (generally within 100 nucleotides). The minimal CPE capable to stimulate elongation of a poly(A) tail appears to be UUUUAU, and recent experiments show also the existence of substantial context and position effects on CPE function.
Feature Key CPE
ID [1]
Authors Vassalli J-D & Stutz A
Title Translational control: awakening dormant mRNAs
Citation Curr Biol 5: 476-479
Year 1996
ID [2]
Authors Wickens M, Kimble J & Strickland S
Title Translational control of developmental decisions
Citation Cold Spring Harbor, Laboratory Press, pp. 411-450
Year 1996
ID [3]
Authors Verrotti AC, Thompson SR, Wreden C, Strickland S & Wickens M
Title Evolutionary coservation of sequence elements controlling cytoplasmic polyadenylation
Citation Proc Natl Acad Sci 93: 9027-9032
Year 1996