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::General Information
ID U0007
Creation Date 30 September 1997
Updating Date 30 September 1997
Standard Name TGE translational regulation element (TGE)
UTRSite Pattern
suca 5...14 mm uuuc yy 4...9 uwucu
Random Expectation 9.0000000000 hits/kb
::Taxonomy
UTR Region 3'
Taxon Range Metazoa
::Description
Description In the nematode C. elegans sex determining gene tra-2 is involved in the specification of hermaphrodite rather that female development. Negative regulation of tra-2 allow development of XX animals as hermaphrodite rather than female. This regulation is in both germ line and soma and it is necessary for normal male development. A regulatory element in the tra-2 3'-UTR, consisting in a 28 nt direct repeat, also termed DRE (Direct Repeat Element), has been found to be necessary for negative regulation of tra-2 allowing the onset of spermatogenesis. Regulation is mediated at translational level, probably by a trans-acting protein factor called DRF (direct Repeat Factor) with binding activity to DRE. DRE consists in two copies of a 28 nt sequence separated by 4 nt. It has been proposed that when no DRF is bound, translation is not inhibited. Binding of a single repeat cause partial regulation, and the binding to both repeats causes full inhibition. No stable secondary structure was predicted for the DREs by computer analysis. Elements functionally equivalent to DREs have been found in the tra-2 gene of the nematode C. Briggsae and in the human oncogene GLI. For this reason DRE has been renamed TGE (tra-2 and GLI elements). Possible mechanisms are that these regulatory elements may control the length of the poly-A tail, which in turn may influence translation. Alternatively, the TGEs may sequester mRNA away from the translation machinery or they can directly inhibit the interaction of initiation factors or of ribosomal subunits with the 5'-UTR.
::Features
Feature Key TGE
::Transcript(s) / Gene(s)
UTR(s)
Description Species Link Ref.
3'UTR in Caenorhabditis elegans TRAnsformer XX animals transformed into males family member (tra-2), mRNA Caenorhabditis elegans UTRef: 3CELR002296 [U1]
Transcript(s)
Description Species Link Ref.
Caenorhabditis elegans TRAnsformer : XX animals transformed into males family member (tra-2) (tra-2) mRNA, complete cds. Caenorhabditis elegans RefSeq: NM_063025
Gene(s)
Description Species Link Ref.
Tra-2. Caenorhabditis elegans EntrezGene: 174137
::References
ID [1]
Authors Goodwin EB, Okkema PG, Evans TC and Kimble J
Title Translational regulation of tra-2 by its 3' untranslated region controls sexual identity in C. elegans
Citation Cell 75: 329-339
Year 1993
ID [U1]
Authors Goodwin EB, Okkema PG, Evans TC and Kimble J
Title Translational regulation of tra-2 by its 3' untranslated region controls sexual identity in C. elegans
Citation Cell 75: 329-339
Year 1993