Signal Manager :: View

::General Information
ID	U0007
Creation Date	30 September 1997
Updating Date	30 September 1997
Standard Name	TGE translational regulation element (TGE)
UTRSite Pattern	suca 5...14 mm uuuc yy 4...9 uwucu
Random Expectation	9.0000000000 hits/kb
::Taxonomy
UTR Region	3'
Taxon Range	Metazoa
::Description
Description	In the nematode C. elegans sex determining gene tra-2 is involved in the specification of hermaphrodite rather that female development. Negative regulation of tra-2 allow development of XX animals as hermaphrodite rather than female. This regulation is in both germ line and soma and it is necessary for normal male development. A regulatory element in the tra-2 3'-UTR, consisting in a 28 nt direct repeat, also termed DRE (Direct Repeat Element), has been found to be necessary for n......
::Features
Feature Key	TGE
::Transcript(s) / Gene(s)
UTR(s)	Description Species Link Ref. 3'UTR in Caenorhabditis elegans TRAnsformer XX animals transformed into males family member (tra-2), mRNA Caenorhabditis elegans UTRef: 3CELR002296 [U1]
Transcript(s)	Description Species Link Ref. Caenorhabditis elegans TRAnsformer : XX animals transformed into males family member (tra-2) (tra-2) mRNA, complete cds. Caenorhabditis elegans RefSeq: NM_063025
Gene(s)	Description Species Link Ref. Tra-2. Caenorhabditis elegans EntrezGene: 174137
::References
ID	[1]
Authors	Goodwin EB, Okkema PG, Evans TC and Kimble J
Title	Translational regulation of tra-2 by its 3' untranslated region controls sexual identity in C. elegans
Citation	Cell 75: 329-339
Year	1993
ID	[U1]
Authors	Goodwin EB, Okkema PG, Evans TC and Kimble J
Title	Translational regulation of tra-2 by its 3' untranslated region controls sexual identity in C. elegans
Citation	Cell 75: 329-339
Year	1993