References

UTRdb and UTRsite (RELEASE 2010): a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs.
Nucleic Acids Res. 2010; 38 (Database issue): D75-D80.

UTRdb and UTRsite: a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs.
Nucleic Acids Res. 2005 Jan 1; 33 (Database issue): D141-6.

UTRdb and UTRsite: specialized databases of sequences and functional elements of 5' and 3' untranslated regions of eukaryotic mRNAs. Update 2002.
Nucleic Acids Res. 2002 Jan 1; 30 (1): 335-40.

UTRdb and UTRsite: specialized databases of sequences and functional elements of 5' and 3' untranslated regions of eukaryotic mRNAs.
Nucleic Acids Res. 2000 Jan 1; 28 (1): 193-6

Signal Manager :: View

::General Information

ID U0009

Creation Date 30 September 1997

Updating Date 30 September 1997

Standard Name 15-Lipoxygenase Differentiation Control Element (15-LOX-DICE)

UTRSite Pattern

20 > repeat (cccyryccucy[1,1,0] p1=1...7 ang) 0...0 > 1

::Taxonomy

UTR Region 3'

Taxon Range Vertebrata

::Description

Description Erythroid 15-lipoxygenase (15-LOX) synthesized in the early stages of erytropoiesis catalyses the degradation of lipids and is an important factor responsible for the degradation of mitochondria during reticulocyte maturation. The 3'UTR of 15-LOX mRNA contains tandem repeat sequences, referred to as "DICE" for "DIfferentiation Control Element" which specifically bind to regulatory proteins, formerly called LOX-BP. This binding specifically inhibits 15-LOX mRNA translation. In rabbit 15-LOX mRNA, there have been found 10 tandem copies of the repeat sequence, but only 4 (3 tandem) in human. Experimentally, a functional DICE consisting of two repeat elements has been described.
The regulatory binding proteins have been identified as hnRNP K and hnRNP E1.

::Features

Feature Key 15-LOX-DICE

::Transcript(s) / Gene(s)

UTR(s)

Description	Species	Link	Ref.
3' UTR in Oryctolagus cuniculus arachidonate 15 lipoxygenase (ALOX15), mRNA.	Oryctolagus cuniculus	UTRef: 3OCUR000597	[U1][U2]

Transcript(s)

Description	Species	Link	Ref.
Oryctolagus cuniculus arachidonate 15 lipoxygenase (ALOX15), mRNA.	Oryctolagus cuniculus	RefSeq: NM_001082282	[T1][T2][T3]

Gene(s)

Description	Species	Link	Ref.
arachidonate 15 lipoxygenase (ALOX15).	Oryctolagus cuniculus	EntrezGene: 100009114	[G1][G2][G3]

::Protein(s)

Binding Protein(s)

Description	Species	Link	Ref.
hnRNP-K protein, Oryctolagus cuniculus.	Oryctolagus cuniculus	UniProt: O19049	[B1][B2]

::References

ID [1]

Authors Ostareck-Lederer A, Ostareck D.H., Standart N and Thiele BJ

Title Translation of 15-lipoxygenase mRNA is inhibited by a protein that binds to a repeated sequence in the 3'untranslated region

Citation EMBO J 13: 1476-1481

Year 1994

ID [2]

Authors Ostareck D.H., Ostareck-Lederer A., M.Wilm, B.J., Thiele M., Mann and Hentze M.W.

Title Silencing in Erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-Lipoxygenase Translation from the 3' End

Citation Cell 89, 597-606

Year 1997

ID [3]

Authors Ostareck-Lederer A, Ostareck D.H., and Hentze M.W.

Title Cytoplasmic regulatory functions of the KH-domain protein hnRNPs K and E1/E2

Citation Trends in Biochem. Sci 23, 409-411

Year 1998

ID [U1]

Authors Ostareck D.H., Ostareck-Lederer A., M.Wilm, B.J., Thiele M., Mann and Hentze M.W.

Title Silencing in Erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-Lipoxygenase Translation from the 3' End

Citation Cell 89, 597-606

Year 1997

ID [U2]

Authors Ostareck-Lederer A, Ostareck D.H., and Hentze M.W.

Title Cytoplasmic regulatory functions of the KH-domain protein hnRNPs K and E1/E2

Citation Trends in Biochem. Sci 23, 409-411

Year 1998

ID [T1]

Authors Ostareck-Lederer A, Ostareck D.H., Standart N and Thiele BJ

Title Translation of 15-lipoxygenase mRNA is inhibited by a protein that binds to a repeated sequence in the 3'untranslated region

Citation EMBO J 13: 1476-1481

Year 1994

ID [T2]

Authors Ostareck D.H., Ostareck-Lederer A., M.Wilm, B.J., Thiele M., Mann and Hentze M.W.

Title Silencing in Erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-Lipoxygenase Translation from the 3' End

Citation Cell 89, 597-606

Year 1997

ID [T3]

Authors Ostareck-Lederer A, Ostareck D.H., and Hentze M.W.

Title Cytoplasmic regulatory functions of the KH-domain protein hnRNPs K and E1/E2

Citation Trends in Biochem. Sci 23, 409-411

Year 1998

ID [G1]

Authors Ostareck-Lederer A, Ostareck D.H., Standart N and Thiele BJ

Title Translation of 15-lipoxygenase mRNA is inhibited by a protein that binds to a repeated sequence in the 3'untranslated region

Citation EMBO J 13: 1476-1481

Year 1994

ID [G2]

Authors Ostareck D.H., Ostareck-Lederer A., M.Wilm, B.J., Thiele M., Mann and Hentze M.W.

Title Silencing in Erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-Lipoxygenase Translation from the 3' End

Citation Cell 89, 597-606

Year 1997

ID [G3]

Authors Ostareck-Lederer A, Ostareck D.H., and Hentze M.W.

Title Cytoplasmic regulatory functions of the KH-domain protein hnRNPs K and E1/E2

Citation Trends in Biochem. Sci 23, 409-411

Year 1998

ID [B1]

Authors Ostareck D.H., Ostareck-Lederer A., M.Wilm, B.J., Thiele M., Mann and Hentze M.W.

Title Silencing in Erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-Lipoxygenase Translation from the 3' End

Citation Cell 89, 597-606

Year 1997

ID [B2]

Authors Ostareck-Lederer A, Ostareck D.H., and Hentze M.W.

Title Cytoplasmic regulatory functions of the KH-domain protein hnRNPs K and E1/E2

Citation Trends in Biochem. Sci 23, 409-411

Year 1998

Links