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References
UTRdb and UTRsite (RELEASE 2010): a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs.
Nucleic Acids Res. 2010; 38 (Database issue): D75-D80.

UTRdb and UTRsite: a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs.
Nucleic Acids Res. 2005 Jan 1; 33 (Database issue): D141-6.

UTRdb and UTRsite: specialized databases of sequences and functional elements of 5' and 3' untranslated regions of eukaryotic mRNAs. Update 2002.
Nucleic Acids Res. 2002 Jan 1; 30 (1): 335-40.

UTRdb and UTRsite: specialized databases of sequences and functional elements of 5' and 3' untranslated regions of eukaryotic mRNAs.
Nucleic Acids Res. 2000 Jan 1; 28 (1): 193-6

Signal Manager :: View

::General Information
ID U0009
Creation Date 30 September 1997
Updating Date 30 September 1997
Standard Name 15-Lipoxygenase Differentiation Control Element (15-LOX-DICE)
UTRSite Pattern
20 > repeat (cccyryccucy[1,1,0] p1=1...7 ang) 0...0 > 1
::Taxonomy
UTR Region 3'
Taxon Range Vertebrata
::Description
Description Erythroid 15-lipoxygenase (15-LOX) synthesized in the early stages of erytropoiesis catalyses the degradation of lipids and is an important factor responsible for the degradation of mitochondria during reticulocyte maturation. The 3'UTR of 15-LOX mRNA contains tandem repeat sequences, referred to as "DICE" for "DIfferentiation Control Element" which specifically bind to regulatory proteins, formerly called LOX-BP. This binding specifically inhibits 15-LOX mRNA translation. In......
::Features
Feature Key 15-LOX-DICE
::Transcript(s) / Gene(s)
UTR(s)
Description Species Link Ref.
3' UTR in Oryctolagus cuniculus arachidonate 15 lipoxygenase (ALOX15), mRNA. Oryctolagus cuniculus UTRef: 3OCUR000597 [U1][U2]
Transcript(s)
Description Species Link Ref.
Oryctolagus cuniculus arachidonate 15 lipoxygenase (ALOX15), mRNA. Oryctolagus cuniculus RefSeq: NM_001082282 [T1][T2][T3]
Gene(s)
Description Species Link Ref.
arachidonate 15 lipoxygenase (ALOX15). Oryctolagus cuniculus EntrezGene: 100009114 [G1][G2][G3]
::Protein(s)
Binding Protein(s)
Description Species Link Ref.
hnRNP-K protein, Oryctolagus cuniculus. Oryctolagus cuniculus UniProt: O19049 [B1][B2]
::References
ID [1]
Authors Ostareck-Lederer A, Ostareck D.H., Standart N and Thiele BJ
Title Translation of 15-lipoxygenase mRNA is inhibited by a protein that binds to a repeated sequence in the 3'untranslated region
Citation EMBO J 13: 1476-1481
Year 1994
ID [2]
Authors Ostareck D.H., Ostareck-Lederer A., M.Wilm, B.J., Thiele M., Mann and Hentze M.W.
Title Silencing in Erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-Lipoxygenase Translation from the 3' End
Citation Cell 89, 597-606
Year 1997
ID [3]
Authors Ostareck-Lederer A, Ostareck D.H., and Hentze M.W.
Title Cytoplasmic regulatory functions of the KH-domain protein hnRNPs K and E1/E2
Citation Trends in Biochem. Sci 23, 409-411
Year 1998
ID [U1]
Authors Ostareck D.H., Ostareck-Lederer A., M.Wilm, B.J., Thiele M., Mann and Hentze M.W.
Title Silencing in Erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-Lipoxygenase Translation from the 3' End
Citation Cell 89, 597-606
Year 1997
ID [U2]
Authors Ostareck-Lederer A, Ostareck D.H., and Hentze M.W.
Title Cytoplasmic regulatory functions of the KH-domain protein hnRNPs K and E1/E2
Citation Trends in Biochem. Sci 23, 409-411
Year 1998
ID [T1]
Authors Ostareck-Lederer A, Ostareck D.H., Standart N and Thiele BJ
Title Translation of 15-lipoxygenase mRNA is inhibited by a protein that binds to a repeated sequence in the 3'untranslated region
Citation EMBO J 13: 1476-1481
Year 1994
ID [T2]
Authors Ostareck D.H., Ostareck-Lederer A., M.Wilm, B.J., Thiele M., Mann and Hentze M.W.
Title Silencing in Erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-Lipoxygenase Translation from the 3' End
Citation Cell 89, 597-606
Year 1997
ID [T3]
Authors Ostareck-Lederer A, Ostareck D.H., and Hentze M.W.
Title Cytoplasmic regulatory functions of the KH-domain protein hnRNPs K and E1/E2
Citation Trends in Biochem. Sci 23, 409-411
Year 1998
ID [G1]
Authors Ostareck-Lederer A, Ostareck D.H., Standart N and Thiele BJ
Title Translation of 15-lipoxygenase mRNA is inhibited by a protein that binds to a repeated sequence in the 3'untranslated region
Citation EMBO J 13: 1476-1481
Year 1994
ID [G2]
Authors Ostareck D.H., Ostareck-Lederer A., M.Wilm, B.J., Thiele M., Mann and Hentze M.W.
Title Silencing in Erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-Lipoxygenase Translation from the 3' End
Citation Cell 89, 597-606
Year 1997
ID [G3]
Authors Ostareck-Lederer A, Ostareck D.H., and Hentze M.W.
Title Cytoplasmic regulatory functions of the KH-domain protein hnRNPs K and E1/E2
Citation Trends in Biochem. Sci 23, 409-411
Year 1998
ID [B1]
Authors Ostareck D.H., Ostareck-Lederer A., M.Wilm, B.J., Thiele M., Mann and Hentze M.W.
Title Silencing in Erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-Lipoxygenase Translation from the 3' End
Citation Cell 89, 597-606
Year 1997
ID [B2]
Authors Ostareck-Lederer A, Ostareck D.H., and Hentze M.W.
Title Cytoplasmic regulatory functions of the KH-domain protein hnRNPs K and E1/E2
Citation Trends in Biochem. Sci 23, 409-411
Year 1998
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