Signal Manager :: View

::General Information

ID U0010

Creation Date 30 September 1997

Updating Date 30 September 1997

Standard Name AU-rich class-2 Element (ARE2)

UTRSite Pattern

wwwwwwwwwwwwwwwwwwww[8,0,0]
p1=auuu p2=0...4 p1 p3=0...4 p1 p4=0...4 p1 
p1/p2/p1/p3/p1/p4/p1:(p5=auuuauuua)

Random Expectation 0.0 hits/kb

::Taxonomy

UTR Region 3'

Taxon Range Metazoa

::Description

Description AU-rich elements (AREs) present in the 3'untranslated region of mature lymphokine and cytokine mRNAs regulate mRNA stability and translational efficiency. Based on their sequence features and functional properties AREs can be divided into three classes. Class II AREs direct asynchronous cytoplasmic deadenylation (processive kinetics) generating poly-A(-) mRNAs. Among mRNA with class II ARE in their 3' UTR are GM-CSF, IL-2.The minimum number of AUUUA tandem motifs to activate processive degradation is 4 (of which at least 3 in tandem). Furthermore, an AU-rich region 20-30 nt long immediately 5' to the cluster of AUUUA motifs can greatly enhance the degradation activity.

::Features

Feature Key ARE2

::Transcript(s) / Gene(s)

UTR(s)

Description	Species	Link	Ref.
3' UTR in Homo sapiens colony stimulating factor 2 (granulocyte-macrophage) (CSF2), mRNA.	Homo sapiens	UTRef: 3HSAR031284	[U1]

Transcript(s)

Description	Species	Link	Ref.
Homo sapiens colony stimulating factor 2 (granulocyte-macrophage) (CSF2), mRNA.	Homo sapiens	RefSeq: NM_000758	[T1]

Gene(s)

Description	Species	Link	Ref.
colony stimulating factor 2 (granulocyte-macrophage) (CSF2).	Homo sapiens	EntrezGene: 1437	[G1]

::Protein(s)

Binding Protein(s)

Description	Species	Link	Ref.
glyceraldehyde-3-phosphate dehydrogenase ,Homo sapiens.	Homo sapiens	RefSeq: NP_002037	[B1]

::References

ID [1]

Authors Chen CA and Shyu AB

Title AU-rich elements:characterization and importance in mRNA degradation