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::General Information
ID U0010
Creation Date 30 September 1997
Updating Date 30 September 1997
Standard Name AU-rich class-2 Element (ARE2)
UTRSite Pattern
wwwwwwwwwwwwwwwwwwww[8,0,0]
p1=auuu p2=0...4 p1 p3=0...4 p1 p4=0...4 p1 
p1/p2/p1/p3/p1/p4/p1:(p5=auuuauuua)
Random Expectation 0.0 hits/kb
::Taxonomy
UTR Region 3'
Taxon Range Metazoa
::Description
Description AU-rich elements (AREs) present in the 3'untranslated region of mature lymphokine and cytokine mRNAs regulate mRNA stability and translational efficiency. Based on their sequence features and functional properties AREs can be divided into three classes. Class II AREs direct asynchronous cytoplasmic deadenylation (processive kinetics) generating poly-A(-) mRNAs. Among mRNA with class II ARE in their 3' UTR are GM-CSF, IL-2.The minimum number of AUUUA tandem motifs to activate proces......
::Features
Feature Key ARE2
::Transcript(s) / Gene(s)
UTR(s)
Description Species Link Ref.
3' UTR in Homo sapiens colony stimulating factor 2 (granulocyte-macrophage) (CSF2), mRNA. Homo sapiens UTRef: 3HSAR031284 [U1]
Transcript(s)
Description Species Link Ref.
Homo sapiens colony stimulating factor 2 (granulocyte-macrophage) (CSF2), mRNA. Homo sapiens RefSeq: NM_000758 [T1]
Gene(s)
Description Species Link Ref.
colony stimulating factor 2 (granulocyte-macrophage) (CSF2). Homo sapiens EntrezGene: 1437 [G1]
::Protein(s)
Binding Protein(s)
Description Species Link Ref.
glyceraldehyde-3-phosphate dehydrogenase ,Homo sapiens. Homo sapiens RefSeq: NP_002037 [B1]
::References
ID [1]
Authors Chen CA and Shyu AB
Title AU-rich elements:characterization and importance in mRNA degradation
Citation Trends Biochem.Sci.20:465-470
Year 1995
ID [U1]
Authors Chen CA and Shyu AB
Title AU-rich elements:characterization and importance in mRNA degradation
Citation Trends Biochem.Sci.20:465-470
Year 1995
ID [T1]
Authors Chen CA and Shyu AB
Title AU-rich elements:characterization and importance in mRNA degradation
Citation Trends Biochem.Sci.20:465-470
Year 1995
ID [G1]
Authors Chen CA and Shyu AB
Title AU-rich elements:characterization and importance in mRNA degradation
Citation Trends Biochem.Sci.20:465-470
Year 1995
ID [B1]
Authors Chen CA and Shyu AB
Title AU-rich elements:characterization and importance in mRNA degradation
Citation Trends Biochem.Sci.20:465-470
Year 1995