| ID |
U0011 |
|
| Creation Date |
24 July 1998 |
| Updating Date |
24 July 1998 |
|
| Standard Name |
Terminal Oligopyrimidine Tract (TOP) |
| UTRSite Pattern |
^C yyyyyyyyyyyyyy[0,11,0]G
|
| Random Expectation |
0.0 hits/kb |
|
| UTR Region |
5' |
| Taxon Range |
Eukaryota |
|
| Description |
All vertebrate ribosomal protein and translation
elongation factors analyzed to date contain a 5'
terminal oligopyrimidine tract consisting of
5-15 pyrimidines (Kato et al., 1994) that is
required for coordinate translational repression
(Levy et al., 1991; Kaspar et al., 1992) during
growth arrest, differentiation, development and
certain drug treatments (reviewed in Kaspar et al.,
1993; Meyuhas et al., 1996 ). This motif begins with
a C and is followed by a G residue (consensus sequence
C(Py)nG where n=3-14 pyrimidines); otherwise, no other
requirements appear to be necessary except for consecutive
pyrimidines. Deletion of the pyrimidine tract or
exchanging purines for pyrimidines results in unregulated
translation (Levy et al., 1991; Kaspar et al., 1992) .
A protein of ~56 kDa was found which binds to the leaders
of ribosomal proteins L32 and L1 but not to similar mutant
RNAs lacking an intact polypyrimidine tract required for
translational repression (Kaspar et al., 1992; Cardinali et
al., 1993) . Recent results in a Xenopus system suggest
that the La autoantigen may bind to the polypyrimidine
motif and be involved in translational regulation
(Pellizzoni et al., 1996).
|
|
|
|
| Feature Key |
TOP |
|
| UTR(s) |
| Description |
Species |
Link |
Ref. |
| 5'UTR in Mus musculus ribosomal protein L32 (Rpl32), mRNA. |
Mus musculus |
UTRef: 5MMUR020159 |
[U1] |
|
| Transcript(s) |
| Description |
Species |
Link |
Ref. |
| Mus musculus ribosomal protein L32 (Rpl32), mRNA. |
Mus musculus |
RefSeq: NM_172086 |
[T1] |
|
| Gene(s) |
|
|
| Binding Protein(s) |
|
|
| ID |
[1] |
| Authors |
XU N, Chen CA and Shyu AB |
| Title |
Modulation of the fate of cytoplasmic mRNA by AU-rich elements: key sequence features controlling mRNA deadenylation and decay |
| Citation |
Mol. Cell. Biol. 17: 4611-4621 |
| Year |
1997 |
| ID |
[2] |
| Authors |
Cardinali, B., Di Cristina, M. and Pierandrei-Amaldi, P. |
| Title |
Interaction of proteins with the mRNA for ribosomal protein L1 in Xenopus: structural characterization of in vivo complexes and identification of proteins that bind in vitro to its 5'UTR |
| Citation |
Nucleic Acids Res 21: 2301-8 |
| Year |
1993 |
| ID |
[3] |
| Authors |
Kaspar, R.L., Kakegawa, T., Cranston, H., Morris, D.R. and White, M.W. |
| Title |
A regulatory cis element and a specific binding factor involved in the mitogenic control of murine ribosomal protein L32 translation |
| Citation |
J. Biol. Chem. 267: 508-514 |
| Year |
1992 |
| ID |
[4] |
| Authors |
Kaspar, R.L., Morris, D.R. and White, M.W. |
| Title |
Control of ribosomal protein synthesis in eukaryotic cells |
| Citation |
Translational Regulation of Gene Expression 2. New York, Plenum Press |
| Year |
1993 |
| ID |
[5] |
| Authors |
Kato, S., Sekine, S., Oh, S.W., Kim, N.S., Umezawa, Y., Abe, N., Yokoyama-Kobayashi, M. and Aoki, T. |
| Title |
Construction of a human full-length cDNA bank |
| Citation |
Gene 150: 243-50 |
| Year |
1994 |
| ID |
[6] |
| Authors |
Levy, S., Avni, D., Hariharan, N., Perry, R.P. and Meyuhas, O. |
| Title |
Oligopyrimidine Tract at the 5' End of Mammalian Ribosomal Protein mRNAs is Required for their Translational Control |
| Citation |
Proc. Natl. Acad. Sci. USA 88: 3319-3323 |
| Year |
1991 |
| ID |
[7] |
| Authors |
Meyuhas, O., Avni, D. and Shama, S. |
| Title |
Translational control of ribosomal protein mRNAs in eukaryotes |
| Citation |
Translational Control. Cold Spring Harbor, Cold Spring Harbor Laboratory Press. 363-368 |
| Year |
1996 |
| ID |
[8] |
| Authors |
Pellizzoni, L., Cardinali, B., Lin-Marq, N., Mercanti, D. and Pierandrei-Amaldi, P. |
| Title |
A Xenopus laevis homologue of the La autoantigen binds the pyrimidine tract of the 5' UTR of ribosomal protein mRNAs in vitro: implication of a protein factor in complex formation |
| Citation |
J. Mol. Biol 259: 904-15 |
| Year |
1996 |
| ID |
[U1] |
| Authors |
Kaspar, R.L., Kakegawa, T., Cranston, H., Morris, D.R. and White, M.W. |
| Title |
A regulatory cis element and a specific binding factor involved in the mitogenic control of murine ribosomal protein L32 translation |
| Citation |
J. Biol. Chem. 267: 508-514 |
| Year |
1992 |
| ID |
[T1] |
| Authors |
Kaspar, R.L., Kakegawa, T., Cranston, H., Morris, D.R. and White, M.W. |
| Title |
A regulatory cis element and a specific binding factor involved in the mitogenic control of murine ribosomal protein L32 translation |
| Citation |
J. Biol. Chem. 267: 508-514 |
| Year |
1992 |
| ID |
[G1] |
| Authors |
Kaspar, R.L., Kakegawa, T., Cranston, H., Morris, D.R. and White, M.W. |
| Title |
A regulatory cis element and a specific binding factor involved in the mitogenic control of murine ribosomal protein L32 translation |
| Citation |
J. Biol. Chem. 267: 508-514 |
| Year |
1992 |
| ID |
[B1] |
| Authors |
Pellizzoni, L., Cardinali, B., Lin-Marq, N., Mercanti, D. and Pierandrei-Amaldi, P. |
| Title |
A Xenopus laevis homologue of the La autoantigen binds the pyrimidine tract of the 5' UTR of ribosomal protein mRNAs in vitro: implication of a protein factor in complex formation |
| Citation |
J. Mol. Biol 259: 904-15 |
| Year |
1996 |
