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::General Information
ID U0011
Creation Date 24 July 1998
Updating Date 24 July 1998
Standard Name Terminal Oligopyrimidine Tract (TOP)
UTRSite Pattern
^C yyyyyyyyyyyyyy[0,11,0]G
Random Expectation 0.0 hits/kb
::Taxonomy
UTR Region 5'
Taxon Range Eukaryota
::Description
Description All vertebrate ribosomal protein and translation elongation factors analyzed to date contain a 5' terminal oligopyrimidine tract consisting of 5-15 pyrimidines (Kato et al., 1994) that is required for coordinate translational repression (Levy et al., 1991; Kaspar et al., 1992) during growth arrest, differentiation, development and certain drug treatments (reviewed in Kaspar et al., 1993; Meyuhas et al., 1996 ). This motif begins with a C and is followed by a G residue (co......
::Features
Feature Key TOP
::Transcript(s) / Gene(s)
UTR(s)
Description Species Link Ref.
5'UTR in Mus musculus ribosomal protein L32 (Rpl32), mRNA. Mus musculus UTRef: 5MMUR020159 [U1]
Transcript(s)
Description Species Link Ref.
Mus musculus ribosomal protein L32 (Rpl32), mRNA. Mus musculus RefSeq: NM_172086 [T1]
Gene(s)
Description Species Link Ref.
Rpl32 ribosomal protein L32. Mus musculus EntrezGene: 19951 [G1]
::Protein(s)
Binding Protein(s)
Description Species Link Ref.
autoantigen La, Xenopus (Silurana) tropicalis. Xenopus RefSeq: NP_001001455 [B1]
::References
ID [1]
Authors XU N, Chen CA and Shyu AB
Title Modulation of the fate of cytoplasmic mRNA by AU-rich elements: key sequence features controlling mRNA deadenylation and decay
Citation Mol. Cell. Biol. 17: 4611-4621
Year 1997
ID [2]
Authors Cardinali, B., Di Cristina, M. and Pierandrei-Amaldi, P.
Title Interaction of proteins with the mRNA for ribosomal protein L1 in Xenopus: structural characterization of in vivo complexes and identification of proteins that bind in vitro to its 5'UTR
Citation Nucleic Acids Res 21: 2301-8
Year 1993
ID [3]
Authors Kaspar, R.L., Kakegawa, T., Cranston, H., Morris, D.R. and White, M.W.
Title A regulatory cis element and a specific binding factor involved in the mitogenic control of murine ribosomal protein L32 translation
Citation J. Biol. Chem. 267: 508-514
Year 1992
ID [4]
Authors Kaspar, R.L., Morris, D.R. and White, M.W.
Title Control of ribosomal protein synthesis in eukaryotic cells
Citation Translational Regulation of Gene Expression 2. New York, Plenum Press
Year 1993
ID [5]
Authors Kato, S., Sekine, S., Oh, S.W., Kim, N.S., Umezawa, Y., Abe, N., Yokoyama-Kobayashi, M. and Aoki, T.
Title Construction of a human full-length cDNA bank
Citation Gene 150: 243-50
Year 1994
ID [6]
Authors Levy, S., Avni, D., Hariharan, N., Perry, R.P. and Meyuhas, O.
Title Oligopyrimidine Tract at the 5' End of Mammalian Ribosomal Protein mRNAs is Required for their Translational Control
Citation Proc. Natl. Acad. Sci. USA 88: 3319-3323
Year 1991
ID [7]
Authors Meyuhas, O., Avni, D. and Shama, S.
Title Translational control of ribosomal protein mRNAs in eukaryotes
Citation Translational Control. Cold Spring Harbor, Cold Spring Harbor Laboratory Press. 363-368
Year 1996
ID [8]
Authors Pellizzoni, L., Cardinali, B., Lin-Marq, N., Mercanti, D. and Pierandrei-Amaldi, P.
Title A Xenopus laevis homologue of the La autoantigen binds the pyrimidine tract of the 5' UTR of ribosomal protein mRNAs in vitro: implication of a protein factor in complex formation
Citation J. Mol. Biol 259: 904-15
Year 1996
ID [U1]
Authors Kaspar, R.L., Kakegawa, T., Cranston, H., Morris, D.R. and White, M.W.
Title A regulatory cis element and a specific binding factor involved in the mitogenic control of murine ribosomal protein L32 translation
Citation J. Biol. Chem. 267: 508-514
Year 1992
ID [T1]
Authors Kaspar, R.L., Kakegawa, T., Cranston, H., Morris, D.R. and White, M.W.
Title A regulatory cis element and a specific binding factor involved in the mitogenic control of murine ribosomal protein L32 translation
Citation J. Biol. Chem. 267: 508-514
Year 1992
ID [G1]
Authors Kaspar, R.L., Kakegawa, T., Cranston, H., Morris, D.R. and White, M.W.
Title A regulatory cis element and a specific binding factor involved in the mitogenic control of murine ribosomal protein L32 translation
Citation J. Biol. Chem. 267: 508-514
Year 1992
ID [B1]
Authors Pellizzoni, L., Cardinali, B., Lin-Marq, N., Mercanti, D. and Pierandrei-Amaldi, P.
Title A Xenopus laevis homologue of the La autoantigen binds the pyrimidine tract of the 5' UTR of ribosomal protein mRNAs in vitro: implication of a protein factor in complex formation
Citation J. Mol. Biol 259: 904-15
Year 1996