| ID |
U0011 |
|
| Creation Date |
24 July 1998 |
| Updating Date |
24 July 1998 |
|
| Standard Name |
Terminal Oligopyrimidine Tract (TOP) |
| UTRSite Pattern |
^C yyyyyyyyyyyyyy[0,11,0]G
|
| Random Expectation |
0.0 hits/kb |
|
| UTR Region |
5' |
| Taxon Range |
Eukaryota |
|
| Description |
All vertebrate ribosomal protein and translation
elongation factors analyzed to date contain a 5'
terminal oligopyrimidine tract consisting of
5-15 pyrimidines (Kato et al., 1994) that is
required for coordinate translational repression
(Levy et al., 1991; Kaspar et al., 1992) during
growth arrest, differentiation, development and
certain drug treatments (reviewed in Kaspar et al.,
1993; Meyuhas et al., 1996 ). This motif begins with
a C and is followed by a G residue (co...... |
|
|
|
| Feature Key |
TOP |
|
| UTR(s) |
| Description |
Species |
Link |
Ref. |
| 5'UTR in Mus musculus ribosomal protein L32 (Rpl32), mRNA. |
Mus musculus |
UTRef: 5MMUR020159 |
[U1] |
|
| Transcript(s) |
| Description |
Species |
Link |
Ref. |
| Mus musculus ribosomal protein L32 (Rpl32), mRNA. |
Mus musculus |
RefSeq: NM_172086 |
[T1] |
|
| Gene(s) |
|
|
| Binding Protein(s) |
|
|
| ID |
[1] |
| Authors |
XU N, Chen CA and Shyu AB |
| Title |
Modulation of the fate of cytoplasmic mRNA by AU-rich elements: key sequence features controlling mRNA deadenylation and decay |
| Citation |
Mol. Cell. Biol. 17: 4611-4621 |
| Year |
1997 |
| ID |
[2] |
| Authors |
Cardinali, B., Di Cristina, M. and Pierandrei-Amaldi, P. |
| Title |
Interaction of proteins with the mRNA for ribosomal protein L1 in Xenopus: structural characterization of in vivo complexes and identification of proteins that bind in vitro to its 5'UTR |
| Citation |
Nucleic Acids Res 21: 2301-8 |
| Year |
1993 |
| ID |
[3] |
| Authors |
Kaspar, R.L., Kakegawa, T., Cranston, H., Morris, D.R. and White, M.W. |
| Title |
A regulatory cis element and a specific binding factor involved in the mitogenic control of murine ribosomal protein L32 translation |
| Citation |
J. Biol. Chem. 267: 508-514 |
| Year |
1992 |
| ID |
[4] |
| Authors |
Kaspar, R.L., Morris, D.R. and White, M.W. |
| Title |
Control of ribosomal protein synthesis in eukaryotic cells |
| Citation |
Translational Regulation of Gene Expression 2. New York, Plenum Press |
| Year |
1993 |
| ID |
[5] |
| Authors |
Kato, S., Sekine, S., Oh, S.W., Kim, N.S., Umezawa, Y., Abe, N., Yokoyama-Kobayashi, M. and Aoki, T. |
| Title |
Construction of a human full-length cDNA bank |
| Citation |
Gene 150: 243-50 |
| Year |
1994 |
| ID |
[6] |
| Authors |
Levy, S., Avni, D., Hariharan, N., Perry, R.P. and Meyuhas, O. |
| Title |
Oligopyrimidine Tract at the 5' End of Mammalian Ribosomal Protein mRNAs is Required for their Translational Control |
| Citation |
Proc. Natl. Acad. Sci. USA 88: 3319-3323 |
| Year |
1991 |
| ID |
[7] |
| Authors |
Meyuhas, O., Avni, D. and Shama, S. |
| Title |
Translational control of ribosomal protein mRNAs in eukaryotes |
| Citation |
Translational Control. Cold Spring Harbor, Cold Spring Harbor Laboratory Press. 363-368 |
| Year |
1996 |
| ID |
[8] |
| Authors |
Pellizzoni, L., Cardinali, B., Lin-Marq, N., Mercanti, D. and Pierandrei-Amaldi, P. |
| Title |
A Xenopus laevis homologue of the La autoantigen binds the pyrimidine tract of the 5' UTR of ribosomal protein mRNAs in vitro: implication of a protein factor in complex formation |
| Citation |
J. Mol. Biol 259: 904-15 |
| Year |
1996 |
| ID |
[U1] |
| Authors |
Kaspar, R.L., Kakegawa, T., Cranston, H., Morris, D.R. and White, M.W. |
| Title |
A regulatory cis element and a specific binding factor involved in the mitogenic control of murine ribosomal protein L32 translation |
| Citation |
J. Biol. Chem. 267: 508-514 |
| Year |
1992 |
| ID |
[T1] |
| Authors |
Kaspar, R.L., Kakegawa, T., Cranston, H., Morris, D.R. and White, M.W. |
| Title |
A regulatory cis element and a specific binding factor involved in the mitogenic control of murine ribosomal protein L32 translation |
| Citation |
J. Biol. Chem. 267: 508-514 |
| Year |
1992 |
| ID |
[G1] |
| Authors |
Kaspar, R.L., Kakegawa, T., Cranston, H., Morris, D.R. and White, M.W. |
| Title |
A regulatory cis element and a specific binding factor involved in the mitogenic control of murine ribosomal protein L32 translation |
| Citation |
J. Biol. Chem. 267: 508-514 |
| Year |
1992 |
| ID |
[B1] |
| Authors |
Pellizzoni, L., Cardinali, B., Lin-Marq, N., Mercanti, D. and Pierandrei-Amaldi, P. |
| Title |
A Xenopus laevis homologue of the La autoantigen binds the pyrimidine tract of the 5' UTR of ribosomal protein mRNAs in vitro: implication of a protein factor in complex formation |
| Citation |
J. Mol. Biol 259: 904-15 |
| Year |
1996 |
