| ID |
U0012 |
|
| Creation Date |
03 March 1999 |
| Updating Date |
03 March 1999 |
|
| Standard Name |
Glusose transporter type-1 3'UTR cis-acting element (GLUT1) |
| UTRSite Pattern |
ccaaccactc
|
| Random Expectation |
0.0 hits/kb |
|
| UTR Region |
3' |
| Taxon Range |
Vertebrata |
|
| Description |
The 5' and 3' untranslated (UTR) regions of the Na+
independent glucose transporter GLUT1 mRNA are highly
conserved among species being embedded of several
cis-acting regulatory elements which either stabilize
or destabilize the mRNA subsequent to the binding of
specific cytosolic or polysome proteins in response to glucose
deprivation or to brain derived trophic factors.
A 10 nucleotide cis-acting element, located in the
GLUT1 3'-UTR region, has been shown to increase GLUT1
gene expression via specific binding to a 80 kDa protein,
expressed in human brain hemangioblastoma and in the C6
rat brain glioma, which mediates mRNA stabilization.
|
|
|
|
| Feature Key |
GLUT1 |
|
| UTR(s) |
| Description |
Species |
Link |
Ref. |
| 3' UTR in Bos taurus solute carrier family 2 (facilitated glucose transporter), member 1 (SLC2A1),mRNA. |
Bos taurus |
UTRef: 3BTAR002231 |
[U1] |
|
| Transcript(s) |
| Description |
Species |
Link |
Ref. |
| Bos taurus solute carrier family 2 (facilitated glucose transporter), member 1 (SLC2A1),mRNA. |
Bos taurus |
RefSeq: NM_174602 |
[T1] |
|
| Gene(s) |
| Description |
Species |
Link |
Ref. |
| solute carrier family 2 (facilitated glucose transporter), member 1 (SLC2A1). |
Bos taurus |
EntrezGene: 282356 |
[G1] |
|
|
| ID |
[1] |
| Authors |
Boado R.J. and Pardridge W.M. |
| Title |
Ten nucleotide cis element in the 3'-untranslated region of the GLUT1 glucose transporter mRNA increases gene expression via mRNA stabilization |
| Citation |
Mol. Brain Res. 59: 109-113 |
| Year |
1998 |
| ID |
[U1] |
| Authors |
Boado R.J. and Pardridge W.M. |
| Title |
Ten nucleotide cis element in the 3'-untranslated region of the GLUT1 glucose transporter mRNA increases gene expression via mRNA stabilization |
| Citation |
Mol. Brain Res. 59: 109-113 |
| Year |
1998 |
| ID |
[T1] |
| Authors |
Boado R.J. and Pardridge W.M. |
| Title |
Ten nucleotide cis element in the 3'-untranslated region of the GLUT1 glucose transporter mRNA increases gene expression via mRNA stabilization |
| Citation |
Mol. Brain Res. 59: 109-113 |
| Year |
1998 |
| ID |
[G1] |
| Authors |
Boado R.J. and Pardridge W.M. |
| Title |
Ten nucleotide cis element in the 3'-untranslated region of the GLUT1 glucose transporter mRNA increases gene expression via mRNA stabilization |
| Citation |
Mol. Brain Res. 59: 109-113 |
| Year |
1998 |
