| ID |
U0013 |
|
| Creation Date |
03 March 1999 |
| Updating Date |
03 March 1999 |
|
| Standard Name |
Tumor necrosis factor alpha 3'UTR cis-acting element (TNF) |
| UTRSite Pattern |
uuauguuu 0...8 ar auauuuau surayynrru ugucw
|
| Random Expectation |
0.0 hits/kb |
|
| UTR Region |
3' |
| Taxon Range |
Vertebrata |
|
| Description |
Tumor necrosis factor alpha (TNF-alpha) is a key cytokine
regulator of the immune process and of the tissue homeostasis.
The production of TNF-alpha is mainly controlled
post-trascriptionally by cis-elements located in the
3'-UTR and which regulate mRNA stability and translation
efficency. In addition to a class II AU-rich element
(ARE2) previously found in the 3'-UTR of TNF-alpha mRNA,
another RNA binding motif has been characterized
about 150 nt downstream. This element contains a consensus
core of AUAUUUA, which is highly conserved in evolution,
and has been suggested to synergize with the ARE2 element
in the repression of TNF-alpha mRNA translation and in the
regulation of translation.
|
|
|
|
| Feature Key |
TNF |
|
| UTR(s) |
| Description |
Species |
Link |
Ref. |
| 3' UTR in Mus musculus tumor necrosis factor (Tnf), mRNA. |
Mus musculus |
UTRef: 3MMUR059721 |
[U1] |
|
| Transcript(s) |
| Description |
Species |
Link |
Ref. |
| Mus musculus tumor necrosis factor (Tnf), mRNA. |
Mus musculus |
RefSeq: NM_013693 |
[T1] |
|
| Gene(s) |
|
|
| ID |
[1] |
| Authors |
Hel Z, Di Marco S and Radzioch D |
| Title |
Characterization of the RNA binding proteins forming complexes with a novel putative regulatory region in the 3'-UTR of TNF-alpha mRNA |
| Citation |
Nucleic Acids Res. 26: 2803-2812 |
| Year |
1998 |
| ID |
[U1] |
| Authors |
Hel Z, Di Marco S and Radzioch D |
| Title |
Characterization of the RNA binding proteins forming complexes with a novel putative regulatory region in the 3'-UTR of TNF-alpha mRNA |
| Citation |
Nucleic Acids Res. 26: 2803-2812 |
| Year |
1998 |
| ID |
[T1] |
| Authors |
Hel Z, Di Marco S and Radzioch D |
| Title |
Characterization of the RNA binding proteins forming complexes with a novel putative regulatory region in the 3'-UTR of TNF-alpha mRNA |
| Citation |
Nucleic Acids Res. 26: 2803-2812 |
| Year |
1998 |
| ID |
[G1] |
| Authors |
Hel Z, Di Marco S and Radzioch D |
| Title |
Characterization of the RNA binding proteins forming complexes with a novel putative regulatory region in the 3'-UTR of TNF-alpha mRNA |
| Citation |
Nucleic Acids Res. 26: 2803-2812 |
| Year |
1998 |
