Signal Manager :: View

::General Information

ID U0013

Creation Date 03 March 1999

Updating Date 03 March 1999

Standard Name Tumor necrosis factor alpha 3'UTR cis-acting element (TNF)

UTRSite Pattern

uuauguuu 0...8 ar auauuuau surayynrru ugucw

Random Expectation 0.0 hits/kb

::Taxonomy

UTR Region 3'

Taxon Range Vertebrata

::Description

Description Tumor necrosis factor alpha (TNF-alpha) is a key cytokine regulator of the immune process and of the tissue homeostasis. The production of TNF-alpha is mainly controlled post-trascriptionally by cis-elements located in the 3'-UTR and which regulate mRNA stability and translation efficency. In addition to a class II AU-rich element (ARE2) previously found in the 3'-UTR of TNF-alpha mRNA, another RNA binding motif has been characterized about 150 nt downstream. This element contains ......

::Features

Feature Key TNF

::Transcript(s) / Gene(s)

UTR(s)

Description	Species	Link	Ref.
3' UTR in Mus musculus tumor necrosis factor (Tnf), mRNA.	Mus musculus	UTRef: 3MMUR059721	[U1]

Transcript(s)

Description	Species	Link	Ref.
Mus musculus tumor necrosis factor (Tnf), mRNA.	Mus musculus	RefSeq: NM_013693	[T1]

Gene(s)

Description	Species	Link	Ref.
tumor necrosis factor (Tnf).	Mus musculus	EntrezGene: 21926	[G1]

::References

ID [1]

Authors Hel Z, Di Marco S and Radzioch D

Title Characterization of the RNA binding proteins forming complexes with a novel putative regulatory region in the 3'-UTR of TNF-alpha mRNA

Citation Nucleic Acids Res. 26: 2803-2812

Year 1998

ID [U1]

Authors Hel Z, Di Marco S and Radzioch D

Title Characterization of the RNA binding proteins forming complexes with a novel putative regulatory region in the 3'-UTR of TNF-alpha mRNA

Citation Nucleic Acids Res. 26: 2803-2812

Year 1998

ID [T1]

Authors Hel Z, Di Marco S and Radzioch D

Title Characterization of the RNA binding proteins forming complexes with a novel putative regulatory region in the 3'-UTR of TNF-alpha mRNA

Citation Nucleic Acids Res. 26: 2803-2812

Year 1998

ID [G1]

Authors Hel Z, Di Marco S and Radzioch D

Title Characterization of the RNA binding proteins forming complexes with a novel putative regulatory region in the 3'-UTR of TNF-alpha mRNA

Citation Nucleic Acids Res. 26: 2803-2812

Year 1998