Signal Manager :: View

::General Information

ID U0014

Creation Date 16 September 1999

Updating Date 16 September 1999

Standard Name Vimentin 3'UTR cis-acting element (VIM3)

UTRSite Pattern

p1=yttrrrrraa[2,0,0] 0...4 
p2=cagctttcaagtgccttt[2,0,0] 0...2
p3=tscagtt[2,0,0] 6...7 
p4=gagcg[2,0,0] 0...1 p5=aagatw[2,0,0]
p1/p2/p3/p4/p5:(p6=yttrrrrraacagctttcaagtgccttttscagttgagcgaagatw[2,0,0])

Random Expectation 0.0 hits/kb

::Taxonomy

UTR Region 3'

Taxon Range Vertebrata

::Description

Description Vimentin is an intermediate filement protein whose 3'UTR sequence is highly conserved among vertebrates and has been found to be a target for one or more RNA binding protein which include a 46-and 35-kDa protein plus a minor band containing a 60-kDa protein. The sequences required for binding are contained within a region 61-114 nucleotides downstream the stop codon which is able to fold into a Y-shaped secondary structure confirmed by nuclease and lead cleavage. It has been suggested that this 53 nt conserved region located in the 3'UTR and associated protein(s) might be important for vimentin mRNA function as well as for its localization in the perinuclear region of the cytoplasm possibly at sites of intermediate filament assembly.

::Features

Feature Key VIM3

::Transcript(s) / Gene(s)

UTR(s)

Description	Species	Link	Ref.
3' UTR in Homo sapiens vimentin (VIM), mRNA.	Homo sapiens	UTRef: 3HSAR031179	[U1]

Transcript(s)

Description	Species	Link	Ref.
Homo sapiens vimentin (VIM), mRNA.	Homo sapiens	RefSeq: NM_003380	[T1]

Gene(s)

Description	Species	Link	Ref.
vimentin (VIM).	Homo sapiens	EntrezGene: 7431	[G1]

::References

ID [1]

Authors Zehner ZE, Sheperd RK, Gabryszuk J, Fu T-F, Al-Ali M and Holmes WM.

Title RNA-protein protein interactions within the 3'untranslated region of vimentin mRNA

Citation Nucleic Acids Res. 25: 3362-3370, 1997

Year 1997

ID [U1]

Authors Zehner ZE, Sheperd RK, Gabryszuk J, Fu T-F, Al-Ali M and Holmes WM.

Title RNA-protein protein interactions within the 3'untranslated region of vimentin mRNA

Citation Nucleic Acids Res. 25: 3362-3370, 1997

Year 1997

ID [T1]

Authors Zehner ZE, Sheperd RK, Gabryszuk J, Fu T-F, Al-Ali M and Holmes WM.

Title RNA-protein protein interactions within the 3'untranslated region of vimentin mRNA

Citation Nucleic Acids Res. 25: 3362-3370, 1997

Year 1997

ID [G1]

Authors Zehner ZE, Sheperd RK, Gabryszuk J, Fu T-F, Al-Ali M and Holmes WM.

Title RNA-protein protein interactions within the 3'untranslated region of vimentin mRNA

Citation Nucleic Acids Res. 25: 3362-3370, 1997

Year 1997