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::General Information
ID U0014
Creation Date 16 September 1999
Updating Date 16 September 1999
Standard Name Vimentin 3'UTR cis-acting element (VIM3)
UTRSite Pattern
p1=yttrrrrraa[2,0,0] 0...4 
p2=cagctttcaagtgccttt[2,0,0] 0...2
p3=tscagtt[2,0,0] 6...7 
p4=gagcg[2,0,0] 0...1 p5=aagatw[2,0,0]
p1/p2/p3/p4/p5:(p6=yttrrrrraacagctttcaagtgccttttscagttgagcgaagatw[2,0,0])
Random Expectation 0.0 hits/kb
::Taxonomy
UTR Region 3'
Taxon Range Vertebrata
::Description
Description Vimentin is an intermediate filement protein whose 3'UTR sequence is highly conserved among vertebrates and has been found to be a target for one or more RNA binding protein which include a 46-and 35-kDa protein plus a minor band containing a 60-kDa protein. The sequences required for binding are contained within a region 61-114 nucleotides downstream the stop codon which is able to fold into a Y-shaped secondary structure confirmed by nuclease and lead cleavage. It has been suggested that this 53 nt conserved region located in the 3'UTR and associated protein(s) might be important for vimentin mRNA function as well as for its localization in the perinuclear region of the cytoplasm possibly at sites of intermediate filament assembly.
::Features
Feature Key VIM3
::Transcript(s) / Gene(s)
UTR(s)
Description Species Link Ref.
3' UTR in Homo sapiens vimentin (VIM), mRNA. Homo sapiens UTRef: 3HSAR031179 [U1]
Transcript(s)
Description Species Link Ref.
Homo sapiens vimentin (VIM), mRNA. Homo sapiens RefSeq: NM_003380 [T1]
Gene(s)
Description Species Link Ref.
vimentin (VIM). Homo sapiens EntrezGene: 7431 [G1]
::References
ID [1]
Authors Zehner ZE, Sheperd RK, Gabryszuk J, Fu T-F, Al-Ali M and Holmes WM.
Title RNA-protein protein interactions within the 3'untranslated region of vimentin mRNA
Citation Nucleic Acids Res. 25: 3362-3370, 1997
Year 1997
ID [U1]
Authors Zehner ZE, Sheperd RK, Gabryszuk J, Fu T-F, Al-Ali M and Holmes WM.
Title RNA-protein protein interactions within the 3'untranslated region of vimentin mRNA
Citation Nucleic Acids Res. 25: 3362-3370, 1997
Year 1997
ID [T1]
Authors Zehner ZE, Sheperd RK, Gabryszuk J, Fu T-F, Al-Ali M and Holmes WM.
Title RNA-protein protein interactions within the 3'untranslated region of vimentin mRNA
Citation Nucleic Acids Res. 25: 3362-3370, 1997
Year 1997
ID [G1]
Authors Zehner ZE, Sheperd RK, Gabryszuk J, Fu T-F, Al-Ali M and Holmes WM.
Title RNA-protein protein interactions within the 3'untranslated region of vimentin mRNA
Citation Nucleic Acids Res. 25: 3362-3370, 1997
Year 1997