UTRSite Logo
user: guest
References
UTRdb and UTRsite (RELEASE 2010): a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs.
Nucleic Acids Res. 2010; 38 (Database issue): D75-D80.

UTRdb and UTRsite: a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs.
Nucleic Acids Res. 2005 Jan 1; 33 (Database issue): D141-6.

UTRdb and UTRsite: specialized databases of sequences and functional elements of 5' and 3' untranslated regions of eukaryotic mRNAs. Update 2002.
Nucleic Acids Res. 2002 Jan 1; 30 (1): 335-40.

UTRdb and UTRsite: specialized databases of sequences and functional elements of 5' and 3' untranslated regions of eukaryotic mRNAs.
Nucleic Acids Res. 2000 Jan 1; 28 (1): 193-6

Signal Manager :: View

::General Information
ID U0015
Creation Date 08 May 2000
Updating Date 08 May 2000
Standard Name Internal Ribosome Entry Site (IRES)
UTRSite Pattern
r1={au,ua,cg,gc,gu,ug}
p1=5...6 0...6 p2=5...6 p3=0...2
p4=5...8 p5=3...8
r1~p4[1,0,0] p6=5...8 p7=3...5
r1~p6[1,0,0] p8=0...5
r1~p2[1,0,0] 0...6
r1~p1[1,0,0] 2...5 p9=5...6 p10=3...8
r1~p9[1,0,0] 3...10 ATG 97...97 $
Random Expectation 0.0068809300 hits/kb
::Taxonomy
UTR Region 5'
Taxon Range Eukaryota
::Description
Description Internal mRNA ribosome binding is a mechanism of translation initiation alternative to the conventional 5'-cap dependendent ribosome scanning mechanism. The internal initiation mechanism, first observed in picornavirus, is also found in some cellular mRNAs, such as human immunoglobulin heavy chain binding protein (BiP) mRNA, Antennapedia mRNA of drosophila and FGF-2 mRNA. This mechanism may be advantageous for specific translation of mRNAs during cell cycle when underphosphorilated eIF-4F prevents conventional translation initiation. The internal initiation mechanism is dependent on a cis-acting element, defined as internal ribosome entry site (IRES), located in the 5'UTR region of the mRNA. Comparative analysis of known IRES in some cellular mRNAs identified a common structural motif forming a Y-type stem-loop structure followed by the AUG triplet or followed by additional stem-loop structures and the AUG triplet.
::Features
Feature Key IRES
::Transcript(s) / Gene(s)
UTR(s)
Description Species Link Ref.
5' UTR in Rattus norvegicus fibroblast growth factor 2 (Fgf2), mRNA. Rattus norvegicus UTRef: 5RNOR017863 [U1]
Transcript(s)
Description Species Link Ref.
Rattus norvegicus fibroblast growth factor 2 (Fgf2), mRNA. Rattus norvegicus RefSeq: NM_019305 [T1]
Gene(s)
Description Species Link Ref.
Fgf2 fibroblast growth factor 2. Rattus norvegicus EntrezGene: 54250 [G1]
::References
ID [1]
Authors Le, S.Y., and Maizel,J.V.,Jr.
Title A common RNA structural motif involved in the internal initiation of translation of cellular mRNAs
Citation Nucleic Acids Res.25,362-69
Year 1997
ID [U1]
Authors Le, S.Y., and Maizel,J.V.,Jr.
Title A common RNA structural motif involved in the internal initiation of translation of cellular mRNAs
Citation Nucleic Acids Res.25,362-69
Year 1997
ID [T1]
Authors Le, S.Y., and Maizel,J.V.,Jr.
Title A common RNA structural motif involved in the internal initiation of translation of cellular mRNAs
Citation Nucleic Acids Res.25,362-69
Year 1997
ID [G1]
Authors Le, S.Y., and Maizel,J.V.,Jr.
Title A common RNA structural motif involved in the internal initiation of translation of cellular mRNAs
Citation Nucleic Acids Res.25,362-69
Year 1997
Links