| ID |
U0015 |
|
| Creation Date |
08 May 2000 |
| Updating Date |
08 May 2000 |
|
| Standard Name |
Internal Ribosome Entry Site (IRES) |
| UTRSite Pattern |
r1={au,ua,cg,gc,gu,ug}
p1=5...6 0...6 p2=5...6 p3=0...2
p4=5...8 p5=3...8
r1~p4[1,0,0] p6=5...8 p7=3...5
r1~p6[1,0,0] p8=0...5
r1~p2[1,0,0] 0...6
r1~p1[1,0,0] 2...5 p9=5...6 p10=3...8
r1~p9[1,0,0] 3...10 ATG 97...97 $
|
| Random Expectation |
0.0068809300 hits/kb |
|
| UTR Region |
5' |
| Taxon Range |
Eukaryota |
|
| Description |
Internal mRNA ribosome binding is a mechanism of
translation initiation alternative to the
conventional 5'-cap dependendent ribosome scanning
mechanism.
The internal initiation mechanism, first observed
in picornavirus, is also found in some cellular mRNAs,
such as human immunoglobulin heavy chain binding protein
(BiP) mRNA, Antennapedia mRNA of drosophila and FGF-2 mRNA.
This mechanism may be advantageous for specific translation
of mRNAs during cell cycle when underphosphorilated eIF-4F
prevents conventional translation initiation. The internal
initiation mechanism is dependent on a cis-acting element,
defined as internal ribosome entry site (IRES), located
in the 5'UTR region of the mRNA.
Comparative analysis of known IRES in some cellular mRNAs
identified a common structural motif forming a Y-type stem-loop
structure followed by the AUG triplet or followed by additional
stem-loop structures and the AUG triplet.
|
|
|
|
| Feature Key |
IRES |
|
| UTR(s) |
| Description |
Species |
Link |
Ref. |
| 5' UTR in Rattus norvegicus fibroblast growth factor 2 (Fgf2), mRNA.
|
Rattus norvegicus |
UTRef: 5RNOR017863 |
[U1] |
|
| Transcript(s) |
| Description |
Species |
Link |
Ref. |
| Rattus norvegicus fibroblast growth factor 2 (Fgf2), mRNA. |
Rattus norvegicus |
RefSeq: NM_019305 |
[T1] |
|
| Gene(s) |
|
|
| ID |
[1] |
| Authors |
Le, S.Y., and Maizel,J.V.,Jr. |
| Title |
A common RNA structural motif involved in the internal initiation of translation of cellular mRNAs |
| Citation |
Nucleic Acids Res.25,362-69 |
| Year |
1997 |
| ID |
[U1] |
| Authors |
Le, S.Y., and Maizel,J.V.,Jr. |
| Title |
A common RNA structural motif involved in the internal initiation of translation of cellular mRNAs |
| Citation |
Nucleic Acids Res.25,362-69 |
| Year |
1997 |
| ID |
[T1] |
| Authors |
Le, S.Y., and Maizel,J.V.,Jr. |
| Title |
A common RNA structural motif involved in the internal initiation of translation of cellular mRNAs |
| Citation |
Nucleic Acids Res.25,362-69 |
| Year |
1997 |
| ID |
[G1] |
| Authors |
Le, S.Y., and Maizel,J.V.,Jr. |
| Title |
A common RNA structural motif involved in the internal initiation of translation of cellular mRNAs |
| Citation |
Nucleic Acids Res.25,362-69 |
| Year |
1997 |
