| ID |
U0015 |
|
| Creation Date |
08 May 2000 |
| Updating Date |
08 May 2000 |
|
| Standard Name |
Internal Ribosome Entry Site (IRES) |
| UTRSite Pattern |
r1={au,ua,cg,gc,gu,ug}
p1=5...6 0...6 p2=5...6 p3=0...2
p4=5...8 p5=3...8
r1~p4[1,0,0] p6=5...8 p7=3...5
r1~p6[1,0,0] p8=0...5
r1~p2[1,0,0] 0...6
r1~p1[1,0,0] 2...5 p9=5...6 p10=3...8
r1~p9[1,0,0] 3...10 ATG 97...97 $
|
| Random Expectation |
0.0068809300 hits/kb |
|
| UTR Region |
5' |
| Taxon Range |
Eukaryota |
|
| Description |
Internal mRNA ribosome binding is a mechanism of
translation initiation alternative to the
conventional 5'-cap dependendent ribosome scanning
mechanism.
The internal initiation mechanism, first observed
in picornavirus, is also found in some cellular mRNAs,
such as human immunoglobulin heavy chain binding protein
(BiP) mRNA, Antennapedia mRNA of drosophila and FGF-2 mRNA.
This mechanism may be advantageous for specific translation
of mRNAs during cell cycle when underphosphorilat...... |
|
|
|
| Feature Key |
IRES |
|
| UTR(s) |
| Description |
Species |
Link |
Ref. |
| 5' UTR in Rattus norvegicus fibroblast growth factor 2 (Fgf2), mRNA.
|
Rattus norvegicus |
UTRef: 5RNOR017863 |
[U1] |
|
| Transcript(s) |
| Description |
Species |
Link |
Ref. |
| Rattus norvegicus fibroblast growth factor 2 (Fgf2), mRNA. |
Rattus norvegicus |
RefSeq: NM_019305 |
[T1] |
|
| Gene(s) |
|
|
| ID |
[1] |
| Authors |
Le, S.Y., and Maizel,J.V.,Jr. |
| Title |
A common RNA structural motif involved in the internal initiation of translation of cellular mRNAs |
| Citation |
Nucleic Acids Res.25,362-69 |
| Year |
1997 |
| ID |
[U1] |
| Authors |
Le, S.Y., and Maizel,J.V.,Jr. |
| Title |
A common RNA structural motif involved in the internal initiation of translation of cellular mRNAs |
| Citation |
Nucleic Acids Res.25,362-69 |
| Year |
1997 |
| ID |
[T1] |
| Authors |
Le, S.Y., and Maizel,J.V.,Jr. |
| Title |
A common RNA structural motif involved in the internal initiation of translation of cellular mRNAs |
| Citation |
Nucleic Acids Res.25,362-69 |
| Year |
1997 |
| ID |
[G1] |
| Authors |
Le, S.Y., and Maizel,J.V.,Jr. |
| Title |
A common RNA structural motif involved in the internal initiation of translation of cellular mRNAs |
| Citation |
Nucleic Acids Res.25,362-69 |
| Year |
1997 |
