References

UTRdb and UTRsite (RELEASE 2010): a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs.
Nucleic Acids Res. 2010; 38 (Database issue): D75-D80.

UTRdb and UTRsite: a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs.
Nucleic Acids Res. 2005 Jan 1; 33 (Database issue): D141-6.

UTRdb and UTRsite: specialized databases of sequences and functional elements of 5' and 3' untranslated regions of eukaryotic mRNAs. Update 2002.
Nucleic Acids Res. 2002 Jan 1; 30 (1): 335-40.

UTRdb and UTRsite: specialized databases of sequences and functional elements of 5' and 3' untranslated regions of eukaryotic mRNAs.
Nucleic Acids Res. 2000 Jan 1; 28 (1): 193-6

Signal Manager :: View

::General Information

ID U0017

Creation Date 01 September 2005

Updating Date 28 September 2009

Standard Name UNR binding site

UTRSite Pattern

(RRRRRAAGUAR|RRRRRRRRAACRRR)

::Taxonomy

UTR Region All

Taxon Range Metazoa

::Description

Description Upstream of N-ras (UNR) is a cytoplasmic protein containing five cold shock domains (CSD) (Jacquemin- Sablon et al., 1994). Proteins of the CSD family perform a variety of functions and are thought to behave as RNA chaperones, promoting a linear conformation of the mRNA. In humans, UNR has been implicated in the destabilization of c-fos mRNA (Chang et al., 2004) and the activation of translation driven by the IRESs of a number of transcripts, including c-myc (Evans et al., 2003), rhinovirus (H......

::Features

Feature Key UNR-bs

::Transcript(s) / Gene(s)

UTR(s)

Description	Species	Link	Ref.
Apoptotic protease activating factor (Apaf-1) 5'UTR mRNA	Homo sapiens	UTRef: 5HSAR027754	[U1]
c-myc, 5'UTR mRNA.	Homo sapiens	UTRef: 5HSAR031001	[U2]
cell division cycle 2-like 2 (PITSLRE proteins), 5'UTR mRNA.	Homo sapiens	UTRef: BR044502	[U3]

Transcript(s)

Description	Species	Link	Ref.
Apoptotic protease activating factor (Apaf-1) mRNA	Homo sapiens	RefSeq: NM_001160	[T1]
c-myc, mRNA	Homo sapiens	RefSeq: NM_002467	[T2]
cell division cycle 2-like 2 (PITSLRE proteins), mRNA.	Homo sapiens	RefSeq: NM_033537	[T3]
c-fos, mRNA	Homo sapiens	RefSeq: NM_005252	[T4]

Gene(s)

Description	Species	Link	Ref.
PITSLRE serine/threonine-protein kinase CDC2L2	Homo sapiens	ENSEMBL: ENSG00000008128
Myc proto-oncogene protein (c-myc)	Homo sapiens	ENSEMBL: ENSG00000136997
Apoptotic protease activating factor 1 (Apaf-1)	Homo sapiens	ENSEMBL: ENSG00000120868
proto-oncogene c-fos	Homo sapiens	ENSEMBL: ENSG00000170345

::Protein(s)

Binding Protein(s)

Description	Species	Link	Ref.
Cold shock domain protein E1 (UNR protein) (N-ras upstream gene protein)	Homo sapiens	UniProt: O75534	[B1][B2][B3][B4][B5][B6][B7][B8]

Interactor(s) of Binding Protein(s)

Description	Species	Link	Ref.
Polyadenylate-binding protein 1	Homo sapiens	UniProt: P11940	[P1]
Serine-threonine kinase receptor-associated protein (UNR interacting protein)	Homo sapiens	UniProt: Q9Y3F4	[P2]

::References

ID [1]

Authors Boussadia O, Jacquemin-Sablon H, Dautry F.

Title Exon skipping in the expression of the gene immediately upstream of N-ras (unr/NRU).

Citation Biochim Biophys Acta. 1993 Feb 20;1172(1-2):64-72.

Year 1993

ID [2]

Authors Boussadia O, Niepmann M, Creancier L, Prats AC, Dautry F, Jacquemin-Sablon H.

Title Unr is required in vivo for efficient initiation of translation from the internal ribosome entry sites of both rhinovirus and poliovirus.

Citation J Virol. 2003 Mar;77(6):3353-9.

Year 2003

ID [3]

Authors Chang TC, Yamashita A, Chen CY, Yamashita Y, Zhu W, Durdan S, Kahvejian A, Sonenberg N, Shyu AB.

Title UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant.

Citation Genes Dev. 2004 Aug 15;18(16):2010-23.

Year 2004

ID [4]

Authors Evans JR, Mitchell SA, Spriggs KA, Ostrowski J, Bomsztyk K, Ostarek D, Willis AE.

Title Members of the poly (rC) binding protein family stimulate the activity of the c-myc internal ribosome entry segment in vitro and in vivo.

Citation Oncogene. 2003 Sep 11;22(39):8012-20.

Year 2003

ID [5]

Authors Hunt SL, Hsuan JJ, Totty N, Jackson RJ.

Title Unr, a cellular cytoplasmic RNA-binding protein with five cold-shock domains, is required for internal initiation of translation of human rhinovirus RNA.

Citation Genes Dev. 1999 Feb 15;13(4):437-48.

Year 1999

ID [6]

Authors Jacquemin-Sablon H, Triqueneaux G, Deschamps S, le Maire M, Doniger J, Dautry F.

Title Nucleic acid binding and intracellular localization of unr, a protein with five cold shock domains.

Citation Nucleic Acids Res. 1994 Jul 11;22(13):2643-50.

Year 1994

ID [7]

Authors Jeffers M, Paciucci R, Pellicer A.

Title Characterization of unr; a gene closely linked to N-ras.

Citation Nucleic Acids Res. 1990 Aug 25;18(16):4891-9.

Year 1990

ID [8]

Authors Mitchell SA, Brown EC, Coldwell MJ, Jackson RJ, Willis AE.

Title Protein factor requirements of the Apaf-1 internal ribosome entry segment: roles of polypyrimidine tract binding protein and upstream of N-ras.

Citation Mol Cell Biol. 2001 May;21(10):3364-74.

Year 2001

ID [9]

Authors Mitchell SA, Spriggs KA, Coldwell MJ, Jackson RJ, Willis AE.

Title The Apaf-1 internal ribosome entry segment attains the correct structural conformation for function via interactions with PTB and unr.

Citation Mol Cell. 2003 Mar;11(3):757-71.

Year 2003

ID [10]

Authors Tinton SA, Schepens B, Bruynooghe Y, Beyaert R, Cornelis S.

Title Regulation of the cell-cycle-dependent internal ribosome entry site of the PITSLRE protein kinase: roles of Unr (upstream of N-ras) protein and phosphorylated translation initiation factor eIF-2alpha.

Citation Biochem J. 2005 Jan 1;385(Pt 1):155-63.

Year 2005

ID [11]

Authors Triqueneaux G, Velten M, Franzon P, Dautry F, Jacquemin-Sablon H.

Title RNA binding specificity of Unr, a protein with five cold shock domains.

Citation Nucleic Acids Res. 1999 Apr 15;27(8):1926-34.

Year 1999

ID [U1]

Authors Mitchell SA, Spriggs KA, Coldwell MJ, Jackson RJ, Willis AE.

Title The Apaf-1 internal ribosome entry segment attains the correct structural conformation for function via interactions with PTB and unr.

Citation Mol Cell. 2003 Mar;11(3):757-71.

Year 2003

ID [U2]

Authors Mitchell SA, Brown EC, Coldwell MJ, Jackson RJ, Willis AE.

Title Protein factor requirements of the Apaf-1 internal ribosome entry segment: roles of polypyrimidine tract binding protein and upstream of N-ras.

Citation Mol Cell Biol. 2001 May;21(10):3364-74.

Year 2001

ID [U3]

Authors Tinton SA, Schepens B, Bruynooghe Y, Beyaert R, Cornelis S.

Citation Biochem J. 2005 Jan 1;385(Pt 1):155-63.

Year 2005

ID [T1]

Authors Mitchell SA, Spriggs KA, Coldwell MJ, Jackson RJ, Willis AE.

Title The Apaf-1 internal ribosome entry segment attains the correct structural conformation for function via interactions with PTB and unr.

Citation Mol Cell. 2003 Mar;11(3):757-71.

Year 2003

ID [T2]

Authors Mitchell SA, Brown EC, Coldwell MJ, Jackson RJ, Willis AE.

Title Protein factor requirements of the Apaf-1 internal ribosome entry segment: roles of polypyrimidine tract binding protein and upstream of N-ras.

Citation Mol Cell Biol. 2001 May;21(10):3364-74.

Year 2001

ID [T3]

Authors Tinton SA, Schepens B, Bruynooghe Y, Beyaert R, Cornelis S.

Citation Biochem J. 2005 Jan 1;385(Pt 1):155-63.

Year 2005

ID [T4]

Authors Chang TC, Yamashita A, Chen CY, Yamashita Y, Zhu W, Durdan S, Kahvejian A, Sonenberg N, Shyu AB.

Title UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant.

Citation Genes Dev. 2004 Aug 15;18(16):2010-23.

Year 2004

ID [B1]

Authors Chang TC, Yamashita A, Chen CY, Yamashita Y, Zhu W, Durdan S, Kahvejian A, Sonenberg N, Shyu AB.

Title UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant.

Citation Genes Dev. 2004 Aug 15;18(16):2010-23.

Year 2004

ID [B2]

Authors Hunt SL, Hsuan JJ, Totty N, Jackson RJ.

Title Unr, a cellular cytoplasmic RNA-binding protein with five cold-shock domains, is required for internal initiation of translation of human rhinovirus RNA.

Citation Genes Dev. 1999 Feb 15;13(4):437-48.

Year 1999

ID [B3]

Authors Jacquemin-Sablon H, Triqueneaux G, Deschamps S, le Maire M, Doniger J, Dautry F.

Title Nucleic acid binding and intracellular localization of unr, a protein with five cold shock domains.

Citation Nucleic Acids Res. 1994 Jul 11;22(13):2643-50.

Year 1994

ID [B4]

Authors Jeffers M, Paciucci R, Pellicer A.

Title Characterization of unr; a gene closely linked to N-ras.

Citation Nucleic Acids Res. 1990 Aug 25;18(16):4891-9.

Year 1990

ID [B5]

Authors Mitchell SA, Brown EC, Coldwell MJ, Jackson RJ, Willis AE.

Title Protein factor requirements of the Apaf-1 internal ribosome entry segment: roles of polypyrimidine tract binding protein and upstream of N-ras.

Citation Mol Cell Biol. 2001 May;21(10):3364-74.

Year 2001

ID [B6]

Authors Mitchell SA, Spriggs KA, Coldwell MJ, Jackson RJ, Willis AE.

Title The Apaf-1 internal ribosome entry segment attains the correct structural conformation for function via interactions with PTB and unr.

Citation Mol Cell. 2003 Mar;11(3):757-71.

Year 2003

ID [B7]

Authors Tinton SA, Schepens B, Bruynooghe Y, Beyaert R, Cornelis S.

Citation Biochem J. 2005 Jan 1;385(Pt 1):155-63.

Year 2005

ID [B8]

Authors Triqueneaux G, Velten M, Franzon P, Dautry F, Jacquemin-Sablon H.

Title RNA binding specificity of Unr, a protein with five cold shock domains.

Citation Nucleic Acids Res. 1999 Apr 15;27(8):1926-34.

Year 1999

ID [P1]

Authors Chang TC, Yamashita A, Chen CY, Yamashita Y, Zhu W, Durdan S, Kahvejian A, Sonenberg N, Shyu AB.

Title UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant.

Citation Genes Dev. 2004 Aug 15;18(16):2010-23.

Year 2004

ID [P2]

Authors Jeffers M, Paciucci R, Pellicer A.

Title Characterization of unr; a gene closely linked to N-ras.

Citation Nucleic Acids Res. 1990 Aug 25;18(16):4891-9.

Year 1990

Links