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Signal Manager :: View

::General Information
ID U0017
Creation Date 01 September 2005
Updating Date 28 September 2009
Standard Name UNR binding site
UTRSite Pattern 
(RRRRRAAGUAR|RRRRRRRRAACRRR)
::Taxonomy
UTR Region All
Taxon Range Metazoa
::Description
Description Upstream of N-ras (UNR) is a cytoplasmic protein containing five cold shock domains (CSD) (Jacquemin- Sablon et al., 1994). Proteins of the CSD family perform a variety of functions and are thought to behave as RNA chaperones, promoting a linear conformation of the mRNA. In humans, UNR has been implicated in the destabilization of c-fos mRNA (Chang et al., 2004) and the activation of translation driven by the IRESs of a number of transcripts, including c-myc (Evans et al., 2003), rhinovirus (H......
::Features
Feature Key UNR-bs
::Transcript(s) / Gene(s)
UTR(s)
Description Species Link Ref.
Apoptotic protease activating factor (Apaf-1) 5'UTR mRNA Homo sapiens UTRef: 5HSAR027754 [U1]
c-myc, 5'UTR mRNA. Homo sapiens UTRef: 5HSAR031001 [U2]
cell division cycle 2-like 2 (PITSLRE proteins), 5'UTR mRNA. Homo sapiens UTRef: BR044502 [U3]
Transcript(s)
Description Species Link Ref.
Apoptotic protease activating factor (Apaf-1) mRNA Homo sapiens RefSeq: NM_001160 [T1]
c-myc, mRNA Homo sapiens RefSeq: NM_002467 [T2]
cell division cycle 2-like 2 (PITSLRE proteins), mRNA. Homo sapiens RefSeq: NM_033537 [T3]
c-fos, mRNA Homo sapiens RefSeq: NM_005252 [T4]
Gene(s)
Description Species Link Ref.
PITSLRE serine/threonine-protein kinase CDC2L2 Homo sapiens ENSEMBL: ENSG00000008128
Myc proto-oncogene protein (c-myc) Homo sapiens ENSEMBL: ENSG00000136997
Apoptotic protease activating factor 1 (Apaf-1) Homo sapiens ENSEMBL: ENSG00000120868
proto-oncogene c-fos Homo sapiens ENSEMBL: ENSG00000170345
::Protein(s)
Binding Protein(s)
Description Species Link Ref.
Cold shock domain protein E1 (UNR protein) (N-ras upstream gene protein) Homo sapiens UniProt: O75534 [B1][B2][B3][B4][B5][B6][B7][B8]
Interactor(s) of Binding Protein(s)
Description Species Link Ref.
Polyadenylate-binding protein 1 Homo sapiens UniProt: P11940 [P1]
Serine-threonine kinase receptor-associated protein (UNR interacting protein) Homo sapiens UniProt: Q9Y3F4 [P2]
::References
ID [1]
Authors Boussadia O, Jacquemin-Sablon H, Dautry F.
Title Exon skipping in the expression of the gene immediately upstream of N-ras (unr/NRU).
Citation Biochim Biophys Acta. 1993 Feb 20;1172(1-2):64-72.
Year 1993
ID [2]
Authors Boussadia O, Niepmann M, Creancier L, Prats AC, Dautry F, Jacquemin-Sablon H.
Title Unr is required in vivo for efficient initiation of translation from the internal ribosome entry sites of both rhinovirus and poliovirus.
Citation J Virol. 2003 Mar;77(6):3353-9.
Year 2003
ID [3]
Authors Chang TC, Yamashita A, Chen CY, Yamashita Y, Zhu W, Durdan S, Kahvejian A, Sonenberg N, Shyu AB.
Title UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant.
Citation Genes Dev. 2004 Aug 15;18(16):2010-23.
Year 2004
ID [4]
Authors Evans JR, Mitchell SA, Spriggs KA, Ostrowski J, Bomsztyk K, Ostarek D, Willis AE.
Title Members of the poly (rC) binding protein family stimulate the activity of the c-myc internal ribosome entry segment in vitro and in vivo.
Citation Oncogene. 2003 Sep 11;22(39):8012-20.
Year 2003
ID [5]
Authors Hunt SL, Hsuan JJ, Totty N, Jackson RJ.
Title Unr, a cellular cytoplasmic RNA-binding protein with five cold-shock domains, is required for internal initiation of translation of human rhinovirus RNA.
Citation Genes Dev. 1999 Feb 15;13(4):437-48.
Year 1999
ID [6]
Authors Jacquemin-Sablon H, Triqueneaux G, Deschamps S, le Maire M, Doniger J, Dautry F.
Title Nucleic acid binding and intracellular localization of unr, a protein with five cold shock domains.
Citation Nucleic Acids Res. 1994 Jul 11;22(13):2643-50.
Year 1994
ID [7]
Authors Jeffers M, Paciucci R, Pellicer A.
Title Characterization of unr; a gene closely linked to N-ras.
Citation Nucleic Acids Res. 1990 Aug 25;18(16):4891-9.
Year 1990
ID [8]
Authors Mitchell SA, Brown EC, Coldwell MJ, Jackson RJ, Willis AE.
Title Protein factor requirements of the Apaf-1 internal ribosome entry segment: roles of polypyrimidine tract binding protein and upstream of N-ras.
Citation Mol Cell Biol. 2001 May;21(10):3364-74.
Year 2001
ID [9]
Authors Mitchell SA, Spriggs KA, Coldwell MJ, Jackson RJ, Willis AE.
Title The Apaf-1 internal ribosome entry segment attains the correct structural conformation for function via interactions with PTB and unr.
Citation Mol Cell. 2003 Mar;11(3):757-71.
Year 2003
ID [10]
Authors Tinton SA, Schepens B, Bruynooghe Y, Beyaert R, Cornelis S.
Title Regulation of the cell-cycle-dependent internal ribosome entry site of the PITSLRE protein kinase: roles of Unr (upstream of N-ras) protein and phosphorylated translation initiation factor eIF-2alpha.
Citation Biochem J. 2005 Jan 1;385(Pt 1):155-63.
Year 2005
ID [11]
Authors Triqueneaux G, Velten M, Franzon P, Dautry F, Jacquemin-Sablon H.
Title RNA binding specificity of Unr, a protein with five cold shock domains.
Citation Nucleic Acids Res. 1999 Apr 15;27(8):1926-34.
Year 1999
ID [U1]
Authors Mitchell SA, Spriggs KA, Coldwell MJ, Jackson RJ, Willis AE.
Title The Apaf-1 internal ribosome entry segment attains the correct structural conformation for function via interactions with PTB and unr.
Citation Mol Cell. 2003 Mar;11(3):757-71.
Year 2003
ID [U2]
Authors Mitchell SA, Brown EC, Coldwell MJ, Jackson RJ, Willis AE.
Title Protein factor requirements of the Apaf-1 internal ribosome entry segment: roles of polypyrimidine tract binding protein and upstream of N-ras.
Citation Mol Cell Biol. 2001 May;21(10):3364-74.
Year 2001
ID [U3]
Authors Tinton SA, Schepens B, Bruynooghe Y, Beyaert R, Cornelis S.
Title Regulation of the cell-cycle-dependent internal ribosome entry site of the PITSLRE protein kinase: roles of Unr (upstream of N-ras) protein and phosphorylated translation initiation factor eIF-2alpha.
Citation Biochem J. 2005 Jan 1;385(Pt 1):155-63.
Year 2005
ID [T1]
Authors Mitchell SA, Spriggs KA, Coldwell MJ, Jackson RJ, Willis AE.
Title The Apaf-1 internal ribosome entry segment attains the correct structural conformation for function via interactions with PTB and unr.
Citation Mol Cell. 2003 Mar;11(3):757-71.
Year 2003
ID [T2]
Authors Mitchell SA, Brown EC, Coldwell MJ, Jackson RJ, Willis AE.
Title Protein factor requirements of the Apaf-1 internal ribosome entry segment: roles of polypyrimidine tract binding protein and upstream of N-ras.
Citation Mol Cell Biol. 2001 May;21(10):3364-74.
Year 2001
ID [T3]
Authors Tinton SA, Schepens B, Bruynooghe Y, Beyaert R, Cornelis S.
Title Regulation of the cell-cycle-dependent internal ribosome entry site of the PITSLRE protein kinase: roles of Unr (upstream of N-ras) protein and phosphorylated translation initiation factor eIF-2alpha.
Citation Biochem J. 2005 Jan 1;385(Pt 1):155-63.
Year 2005
ID [T4]
Authors Chang TC, Yamashita A, Chen CY, Yamashita Y, Zhu W, Durdan S, Kahvejian A, Sonenberg N, Shyu AB.
Title UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant.
Citation Genes Dev. 2004 Aug 15;18(16):2010-23.
Year 2004
ID [B1]
Authors Chang TC, Yamashita A, Chen CY, Yamashita Y, Zhu W, Durdan S, Kahvejian A, Sonenberg N, Shyu AB.
Title UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant.
Citation Genes Dev. 2004 Aug 15;18(16):2010-23.
Year 2004
ID [B2]
Authors Hunt SL, Hsuan JJ, Totty N, Jackson RJ.
Title Unr, a cellular cytoplasmic RNA-binding protein with five cold-shock domains, is required for internal initiation of translation of human rhinovirus RNA.
Citation Genes Dev. 1999 Feb 15;13(4):437-48.
Year 1999
ID [B3]
Authors Jacquemin-Sablon H, Triqueneaux G, Deschamps S, le Maire M, Doniger J, Dautry F.
Title Nucleic acid binding and intracellular localization of unr, a protein with five cold shock domains.
Citation Nucleic Acids Res. 1994 Jul 11;22(13):2643-50.
Year 1994
ID [B4]
Authors Jeffers M, Paciucci R, Pellicer A.
Title Characterization of unr; a gene closely linked to N-ras.
Citation Nucleic Acids Res. 1990 Aug 25;18(16):4891-9.
Year 1990
ID [B5]
Authors Mitchell SA, Brown EC, Coldwell MJ, Jackson RJ, Willis AE.
Title Protein factor requirements of the Apaf-1 internal ribosome entry segment: roles of polypyrimidine tract binding protein and upstream of N-ras.
Citation Mol Cell Biol. 2001 May;21(10):3364-74.
Year 2001
ID [B6]
Authors Mitchell SA, Spriggs KA, Coldwell MJ, Jackson RJ, Willis AE.
Title The Apaf-1 internal ribosome entry segment attains the correct structural conformation for function via interactions with PTB and unr.
Citation Mol Cell. 2003 Mar;11(3):757-71.
Year 2003
ID [B7]
Authors Tinton SA, Schepens B, Bruynooghe Y, Beyaert R, Cornelis S.
Title Regulation of the cell-cycle-dependent internal ribosome entry site of the PITSLRE protein kinase: roles of Unr (upstream of N-ras) protein and phosphorylated translation initiation factor eIF-2alpha.
Citation Biochem J. 2005 Jan 1;385(Pt 1):155-63.
Year 2005
ID [B8]
Authors Triqueneaux G, Velten M, Franzon P, Dautry F, Jacquemin-Sablon H.
Title RNA binding specificity of Unr, a protein with five cold shock domains.
Citation Nucleic Acids Res. 1999 Apr 15;27(8):1926-34.
Year 1999
ID [P1]
Authors Chang TC, Yamashita A, Chen CY, Yamashita Y, Zhu W, Durdan S, Kahvejian A, Sonenberg N, Shyu AB.
Title UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant.
Citation Genes Dev. 2004 Aug 15;18(16):2010-23.
Year 2004
ID [P2]
Authors Jeffers M, Paciucci R, Pellicer A.
Title Characterization of unr; a gene closely linked to N-ras.
Citation Nucleic Acids Res. 1990 Aug 25;18(16):4891-9.
Year 1990