| ID |
U0019 |
|
| Creation Date |
01 December 2000 |
| Updating Date |
24 September 2009 |
|
| Standard Name |
Bruno 3'UTR responsive element (BRE) |
| UTRSite Pattern |
p1=wuurururuu[1,0,0] p1:(p2=wnurururu) p1:(nngngng[2,0,0]) 0...3
p3=wuurururuu[1,0,0] p3:(p4=wnurururu) p3:(nngngng[2,0,0])
|
| Random Expectation |
0.0002215040 hits/kb |
|
| UTR Region |
3' |
| Taxon Range |
Arthropoda |
|
| Description |
The posterior localization of oskar protein in the posterior
pole of drosophila embryos is requested to direct the
deployment of nanos, the posterior body patterning morphogen
in Drosophila. The regulation mechanism involves translation
repression of oskar mRNA prior to its localization at the
posterior pole of the oocyte. Translation repression is
mediated by the ovarian protein bruno that binds specifically
to a cis-acting element located in the the 3'UTR of the
oskar mRNA made by a tandem repetition of a 10 nt long
consensus sequence.
|
|
|
|
| Feature Key |
BRE |
|
| UTR(s) |
| Description |
Species |
Link |
Ref. |
| 3'UTR in Drosophila melanogaster oskar CG10901-RA, transcript variant A (osk), mRNA. |
|
UTRef: 3DMER011794 |
[U1][U2] |
|
| Transcript(s) |
| Description |
Species |
Link |
Ref. |
| oskar CG10901-RA, transcript variant A (osk), mRNA |
Drosophila melanogaster |
RefSeq: NM_169248 |
[T1] |
|
| Gene(s) |
|
|
| Binding Protein(s) |
|
|
| ID |
[1] |
| Authors |
Castagnetti S, Hentze MW, Ephrussi A, Gebauer F. |
| Title |
Control of oskar mRNA translation by Bruno in a novel cell-free system from Drosophila ovaries |
| Citation |
Development 127(5):1063-8 |
| Year |
2000 |
| ID |
[2] |
| Authors |
Kim-Ha J, Kerr K, Macdonald PM. |
| Title |
Translational regulation of oskar mRNA by bruno, an ovarian RNA-binding protein, is essential |
| Citation |
Cell. 5;81(3):403-412 |
| Year |
1995 |
| ID |
[U1] |
| Authors |
Castagnetti S, Hentze MW, Ephrussi A, Gebauer F. |
| Title |
Control of oskar mRNA translation by Bruno in a novel cell-free system from Drosophila ovaries |
| Citation |
Development 127(5):1063-8 |
| Year |
2000 |
| ID |
[U2] |
| Authors |
Kim-Ha J, Kerr K, Macdonald PM. |
| Title |
Translational regulation of oskar mRNA by bruno, an ovarian RNA-binding protein, is essential |
| Citation |
Cell. 5;81(3):403-412 |
| Year |
1995 |
| ID |
[T1] |
| Authors |
Castagnetti S, Hentze MW, Ephrussi A, Gebauer F. |
| Title |
Control of oskar mRNA translation by Bruno in a novel cell-free system from Drosophila ovaries |
| Citation |
Development 127(5):1063-8 |
| Year |
2000 |
| ID |
[G1] |
| Authors |
Castagnetti S, Hentze MW, Ephrussi A, Gebauer F. |
| Title |
Control of oskar mRNA translation by Bruno in a novel cell-free system from Drosophila ovaries |
| Citation |
Development 127(5):1063-8 |
| Year |
2000 |
| ID |
[B1] |
| Authors |
Castagnetti S, Hentze MW, Ephrussi A, Gebauer F. |
| Title |
Control of oskar mRNA translation by Bruno in a novel cell-free system from Drosophila ovaries |
| Citation |
Development 127(5):1063-8 |
| Year |
2000 |
| ID |
[B2] |
| Authors |
Kim-Ha J, Kerr K, Macdonald PM. |
| Title |
Translational regulation of oskar mRNA by bruno, an ovarian RNA-binding protein, is essential |
| Citation |
Cell. 5;81(3):403-412 |
| Year |
1995 |
