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References
UTRdb and UTRsite (RELEASE 2010): a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs.
Nucleic Acids Res. 2010; 38 (Database issue): D75-D80.

UTRdb and UTRsite: a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs.
Nucleic Acids Res. 2005 Jan 1; 33 (Database issue): D141-6.

UTRdb and UTRsite: specialized databases of sequences and functional elements of 5' and 3' untranslated regions of eukaryotic mRNAs. Update 2002.
Nucleic Acids Res. 2002 Jan 1; 30 (1): 335-40.

UTRdb and UTRsite: specialized databases of sequences and functional elements of 5' and 3' untranslated regions of eukaryotic mRNAs.
Nucleic Acids Res. 2000 Jan 1; 28 (1): 193-6

Signal Manager :: View

::General Information
ID U0019
Creation Date 01 December 2000
Updating Date 24 September 2009
Standard Name Bruno 3'UTR responsive element (BRE)
UTRSite Pattern
p1=wuurururuu[1,0,0]  p1:(p2=wnurururu) p1:(nngngng[2,0,0]) 0...3
p3=wuurururuu[1,0,0]  p3:(p4=wnurururu) p3:(nngngng[2,0,0])
Random Expectation 0.0002215040 hits/kb
::Taxonomy
UTR Region 3'
Taxon Range Arthropoda
::Description
Description The posterior localization of oskar protein in the posterior pole of drosophila embryos is requested to direct the deployment of nanos, the posterior body patterning morphogen in Drosophila. The regulation mechanism involves translation repression of oskar mRNA prior to its localization at the posterior pole of the oocyte. Translation repression is mediated by the ovarian protein bruno that binds specifically to a cis-acting element located in the the 3'UTR of the oskar mRNA made ......
::Features
Feature Key BRE
::Transcript(s) / Gene(s)
UTR(s)
Description Species Link Ref.
3'UTR in Drosophila melanogaster oskar CG10901-RA, transcript variant A (osk), mRNA. UTRef: 3DMER011794 [U1][U2]
Transcript(s)
Description Species Link Ref.
oskar CG10901-RA, transcript variant A (osk), mRNA Drosophila melanogaster RefSeq: NM_169248 [T1]
Gene(s)
Description Species Link Ref.
oskar Drosophila melanogaster EntrezGene: 41066 [G1]
::Protein(s)
Binding Protein(s)
Description Species Link Ref.
Arrest (Bruno) Drosophila melanogaster RefSeq: NP_723737 [B1][B2]
::References
ID [1]
Authors Castagnetti S, Hentze MW, Ephrussi A, Gebauer F.
Title Control of oskar mRNA translation by Bruno in a novel cell-free system from Drosophila ovaries
Citation Development 127(5):1063-8
Year 2000
ID [2]
Authors Kim-Ha J, Kerr K, Macdonald PM.
Title Translational regulation of oskar mRNA by bruno, an ovarian RNA-binding protein, is essential
Citation Cell. 5;81(3):403-412
Year 1995
ID [U1]
Authors Castagnetti S, Hentze MW, Ephrussi A, Gebauer F.
Title Control of oskar mRNA translation by Bruno in a novel cell-free system from Drosophila ovaries
Citation Development 127(5):1063-8
Year 2000
ID [U2]
Authors Kim-Ha J, Kerr K, Macdonald PM.
Title Translational regulation of oskar mRNA by bruno, an ovarian RNA-binding protein, is essential
Citation Cell. 5;81(3):403-412
Year 1995
ID [T1]
Authors Castagnetti S, Hentze MW, Ephrussi A, Gebauer F.
Title Control of oskar mRNA translation by Bruno in a novel cell-free system from Drosophila ovaries
Citation Development 127(5):1063-8
Year 2000
ID [G1]
Authors Castagnetti S, Hentze MW, Ephrussi A, Gebauer F.
Title Control of oskar mRNA translation by Bruno in a novel cell-free system from Drosophila ovaries
Citation Development 127(5):1063-8
Year 2000
ID [B1]
Authors Castagnetti S, Hentze MW, Ephrussi A, Gebauer F.
Title Control of oskar mRNA translation by Bruno in a novel cell-free system from Drosophila ovaries
Citation Development 127(5):1063-8
Year 2000
ID [B2]
Authors Kim-Ha J, Kerr K, Macdonald PM.
Title Translational regulation of oskar mRNA by bruno, an ovarian RNA-binding protein, is essential
Citation Cell. 5;81(3):403-412
Year 1995
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