| ID |
U0020 |
|
| Creation Date |
01 December 2000 |
| Updating Date |
01 December 2000 |
|
| Standard Name |
Alcohol dehydrogenase 3'UTR downregulation control element (ADH_DRE) |
| UTRSite Pattern |
AAGGCTGA
|
| Random Expectation |
0.0135620000 hits/kb |
|
| UTR Region |
3' |
| Taxon Range |
Arthropoda |
|
| Description |
A highly conserved eight base sequence within the 3'
untranslated region of the Drosophila Alcohol dehydrogenase
(Adh) mRNA, identified by phylogenetic analysis, was found
to produce a two-fold downregulation of Adh gene expression.
The experimental assay was carried out by in vitro deletion
mutagenesis followed by P element mediated germline
transformation. Downregulation was found to be the result
of a temporally and spatially generated decrease in the Adh
transcript possibly resulti...... |
|
|
|
| Feature Key |
ADH_DRE |
|
| UTR(s) |
| Description |
Species |
Link |
Ref. |
| 3' UTR in Drosophila melanogaster alcohol dehydrogenase (Adh), transcript variant F, mRNA. |
Drosophila melanogaster |
UTRef: 3DMER017035 |
[U1][U2] |
|
| Transcript(s) |
| Description |
Species |
Link |
Ref. |
| Drosophila melanogaster alcohol dehydrogenase (Adh), transcript variant F, mRNA. |
Drosophila melanogaster |
RefSeq: NM_001032098 |
[T1][T2] |
|
| Gene(s) |
|
|
| ID |
[1] |
| Authors |
Parsch J., Russell JA.,Beerman I., Hartl DL., and Stephan W. |
| Title |
Deletion of a conserved regulatory element in the Drosophila Adh gene leads to increased alcohol dehydrogenase activity but also delays development |
| Citation |
Genetics 156:219-227 |
| Year |
2000 |
| ID |
[2] |
| Authors |
Parsch J.,Stephan W.and Tanda S. |
| Title |
A highly conserved sequence in the 3'-untranslated region of the drosophila Adh gene plays a functional role in Adh expression |
| Citation |
Genetics 151(2):667-674 |
| Year |
1999 |
| ID |
[U1] |
| Authors |
Parsch J., Russell JA.,Beerman I., Hartl DL., and Stephan W. |
| Title |
Deletion of a conserved regulatory element in the Drosophila Adh gene leads to increased alcohol dehydrogenase activity but also delays development |
| Citation |
Genetics 156:219-227 |
| Year |
2000 |
| ID |
[U2] |
| Authors |
Parsch J.,Stephan W.and Tanda S. |
| Title |
A highly conserved sequence in the 3'-untranslated region of the drosophila Adh gene plays a functional role in Adh expression |
| Citation |
Genetics 151(2):667-674 |
| Year |
1999 |
| ID |
[T1] |
| Authors |
Parsch J., Russell JA.,Beerman I., Hartl DL., and Stephan W. |
| Title |
Deletion of a conserved regulatory element in the Drosophila Adh gene leads to increased alcohol dehydrogenase activity but also delays development |
| Citation |
Genetics 156:219-227 |
| Year |
2000 |
| ID |
[T2] |
| Authors |
Parsch J.,Stephan W.and Tanda S. |
| Title |
A highly conserved sequence in the 3'-untranslated region of the drosophila Adh gene plays a functional role in Adh expression |
| Citation |
Genetics 151(2):667-674 |
| Year |
1999 |
| ID |
[G1] |
| Authors |
Parsch J., Russell JA.,Beerman I., Hartl DL., and Stephan W. |
| Title |
Deletion of a conserved regulatory element in the Drosophila Adh gene leads to increased alcohol dehydrogenase activity but also delays development |
| Citation |
Genetics 156:219-227 |
| Year |
2000 |
| ID |
[G2] |
| Authors |
Parsch J.,Stephan W.and Tanda S. |
| Title |
A highly conserved sequence in the 3'-untranslated region of the drosophila Adh gene plays a functional role in Adh expression |
| Citation |
Genetics 151(2):667-674 |
| Year |
1999 |
