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References
UTRdb and UTRsite (RELEASE 2010): a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs.
Nucleic Acids Res. 2010; 38 (Database issue): D75-D80.

UTRdb and UTRsite: a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs.
Nucleic Acids Res. 2005 Jan 1; 33 (Database issue): D141-6.

UTRdb and UTRsite: specialized databases of sequences and functional elements of 5' and 3' untranslated regions of eukaryotic mRNAs. Update 2002.
Nucleic Acids Res. 2002 Jan 1; 30 (1): 335-40.

UTRdb and UTRsite: specialized databases of sequences and functional elements of 5' and 3' untranslated regions of eukaryotic mRNAs.
Nucleic Acids Res. 2000 Jan 1; 28 (1): 193-6

Signal Manager :: View

::General Information
ID U0022
Creation Date 22 November 2002
Updating Date 22 November 2002
Standard Name Proneural Box (PB)
UTRSite Pattern
AAUGGAAGACAAU
Random Expectation 0.0000380273 hits/kb
::Taxonomy
UTR Region 3'
Taxon Range Metazoa
::Description
Description The 3'UTR of three proneural genes (achaete, lethal of scute, and atonal) encoding basic Helix-Loop-Helix (bHLH) transcriptional activators that initiate neurogenesis in Drosophila contain a conserved 13 nt long element, AAUGGAAGACAAU, denoted as the proneural box (PB). The central 7 nt of the PB are exactly complementary to the GY-box (GYB) present in the 3'UTR of many Notch pathway target genes in Drosophila. The predicted duplex interaction, generally more extended than the 7-mer core PB:GYB, might serve to regulate neurogenesis.
::Features
Feature Key PRONEURAL-BOX
::Transcript(s) / Gene(s)
UTR(s)
Description Species Link Ref.
3'UTR in Drosophila melanogaster achaete (ac), mRNA. Drosophila melanogaster UTRef: 3DMER001188 [U1]
Transcript(s)
Description Species Link Ref.
Drosophila melanogaster achaete (ac), mRNA. Drosophila melanogaster RefSeq: NM_057476 [T1]
Gene(s)
Description Species Link Ref.
achaete. Drosophila melanogaster EntrezGene: 30981 [G1]
::References
ID [1]
Authors Lai E.C. & Posakony J.W.
Title Regulation of Drosophila neurogenesis by RNA:RNA duplexes?
Citation Cell 93:1103-1104
Year 1998
ID [2]
Authors Lai, E. C., R. Bodner, J. Kavaler, G. Freschi, and J. W. Posakony
Title Antagonism of Notch signaling activity by members of a novel protein family encoded by the Bearded and Enhancer of split gene complexes
Citation Development 127: 291-306
Year 2000
ID [U1]
Authors Lai E.C. & Posakony J.W.
Title Regulation of Drosophila neurogenesis by RNA:RNA duplexes?
Citation Cell 93:1103-1104
Year 1998
ID [T1]
Authors Lai E.C. & Posakony J.W.
Title Regulation of Drosophila neurogenesis by RNA:RNA duplexes?
Citation Cell 93:1103-1104
Year 1998
ID [G1]
Authors Lai E.C. & Posakony J.W.
Title Regulation of Drosophila neurogenesis by RNA:RNA duplexes?
Citation Cell 93:1103-1104
Year 1998
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