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::General Information
ID U0024
Creation Date 22 November 2002
Updating Date 22 November 2002
Standard Name Brd-Box (Brd)
UTRSite Pattern
AGCTTTA
Random Expectation 0.0796282000 hits/kb
::Taxonomy
UTR Region 3'
Taxon Range Metazoa
::Description
Description Many Notch pathway target genes in Drosophila, including most members of the basic helix-loop-helix repressor family and the Bearded family, contain a series of conserved sequence motifs in their 3' UTRs, including the Brd box, the K box, and the GY box. The Brd box (AGCTTTA) is present in one or more copies in many of these 3'UTRs and mediates negative post-transcriptional regulation by affecting transcript stability and translational efficiency. Regulation by the Brd box is spati......
::Features
Feature Key BRD-BOX
::Transcript(s) / Gene(s)
UTR(s)
Description Species Link Ref.
3' UTR in Drosophila melanogaster bearded (Brd), mRNA. Drosophila melanogaster UTRef: 3DMER010425 [U1]
Transcript(s)
Description Species Link Ref.
Drosophila melanogaster bearded (Brd), mRNA. Drosophila melanogaster RefSeq: NM_057541 [T1]
Gene(s)
Description Species Link Ref.
Brd Bearded. Drosophila melanogaster EntrezGene: 39620 [G1]
::References
ID [1]
Authors Lai et al.
Title The K box, a conserved 3' UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts
Citation Development 125:4077-88
Year 1998
ID [2]
Authors Lai E.C.
Title Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation
Citation Nature Genetics. 30:363-4
Year 2002
ID [U1]
Authors Lai et al.
Title The K box, a conserved 3' UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts
Citation Development 125:4077-88
Year 1998
ID [T1]
Authors Lai et al.
Title The K box, a conserved 3' UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts
Citation Development 125:4077-88
Year 1998
ID [G1]
Authors Lai et al.
Title The K box, a conserved 3' UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts
Citation Development 125:4077-88
Year 1998