| ID |
U0024 |
|
| Creation Date |
22 November 2002 |
| Updating Date |
22 November 2002 |
|
| Standard Name |
Brd-Box (Brd) |
| UTRSite Pattern |
AGCTTTA
|
| Random Expectation |
0.0796282000 hits/kb |
|
| UTR Region |
3' |
| Taxon Range |
Metazoa |
|
| Description |
Many Notch pathway target genes in Drosophila, including most
members of the basic helix-loop-helix repressor family and
the Bearded family, contain a series of conserved sequence motifs
in their 3' UTRs, including the Brd box, the K box, and the GY box.
The Brd box (AGCTTTA) is present in one or more copies in many of
these 3'UTRs and mediates negative post-transcriptional regulation
by affecting transcript stability and translational efficiency.
Regulation by the Brd box is spati...... |
|
|
|
| Feature Key |
BRD-BOX |
|
| UTR(s) |
| Description |
Species |
Link |
Ref. |
| 3' UTR in Drosophila melanogaster bearded (Brd), mRNA. |
Drosophila melanogaster |
UTRef: 3DMER010425 |
[U1] |
|
| Transcript(s) |
| Description |
Species |
Link |
Ref. |
| Drosophila melanogaster bearded (Brd), mRNA. |
Drosophila melanogaster |
RefSeq: NM_057541 |
[T1] |
|
| Gene(s) |
|
|
| ID |
[1] |
| Authors |
Lai et al. |
| Title |
The K box, a conserved 3' UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts |
| Citation |
Development 125:4077-88 |
| Year |
1998 |
| ID |
[2] |
| Authors |
Lai E.C. |
| Title |
Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation |
| Citation |
Nature Genetics. 30:363-4 |
| Year |
2002 |
| ID |
[U1] |
| Authors |
Lai et al. |
| Title |
The K box, a conserved 3' UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts |
| Citation |
Development 125:4077-88 |
| Year |
1998 |
| ID |
[T1] |
| Authors |
Lai et al. |
| Title |
The K box, a conserved 3' UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts |
| Citation |
Development 125:4077-88 |
| Year |
1998 |
| ID |
[G1] |
| Authors |
Lai et al. |
| Title |
The K box, a conserved 3' UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts |
| Citation |
Development 125:4077-88 |
| Year |
1998 |
