| ID |
U0025 |
|
| Creation Date |
22 November 2002 |
| Updating Date |
22 November 2002 |
|
| Standard Name |
GY-Box (GY) |
| UTRSite Pattern |
GTCTTCC
|
| Random Expectation |
0.0488070000 hits/kb |
|
| UTR Region |
3' |
| Taxon Range |
Metazoa |
|
| Description |
Many Notch pathway target genes in Drosophila, including most
members of the basic helix-loop-helix repressor family and the
Bearded family, contain a series of conserved sequence motifs in
their 3' UTRs, including the Brd box, the K box, and the GY box.
The GY box (GTCTTCC) is present in one or more copies in several
of these 3' UTRs, but does not appear to have strong cis-regulatory
activity. However, its function likely involves the formation of
RNA duplexes with (1) a complementary sequence found in the 3' UTRs
of proneural basic helix-loop-helix genes (the proneural box,
ATGGAAGACAAT) and (2) with complementary sequences found at the
5' ends of certain micro RNAs (miRNAs).
|
|
|
|
| Feature Key |
GY-BOX |
|
| UTR(s) |
| Description |
Species |
Link |
Ref. |
| 3' UTR in Drosophila melanogaster bearded (Brd), mRNA. |
Drosophila melanogaster |
UTRef: 3DMER010425 |
[U1] |
|
| Transcript(s) |
| Description |
Species |
Link |
Ref. |
| Drosophila melanogaster bearded (Brd), mRNA. |
Drosophila melanogaster |
RefSeq: NM_057541 |
[T1] |
|
| Gene(s) |
|
|
| ID |
[1] |
| Authors |
Lai, E. C., R. Bodner, J. Kavaler, G. Freschi, and J. W. Posakony |
| Title |
Antagonism of Notch signaling activity by members of a novel protein family encoded by the Bearded and Enhancer of split gene complexes |
| Citation |
Development 127: 291-306 |
| Year |
2000 |
| ID |
[2] |
| Authors |
Lai et al. |
| Title |
The K box, a conserved 3' UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts |
| Citation |
Development 125:4077-88 |
| Year |
1998 |
| ID |
[3] |
| Authors |
Lai E.C. |
| Title |
Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation |
| Citation |
Nature Genetics. 30:363-4 |
| Year |
2002 |
| ID |
[U1] |
| Authors |
Lai et al. |
| Title |
The K box, a conserved 3' UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts |
| Citation |
Development 125:4077-88 |
| Year |
1998 |
| ID |
[T1] |
| Authors |
Lai et al. |
| Title |
The K box, a conserved 3' UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts |
| Citation |
Development 125:4077-88 |
| Year |
1998 |
| ID |
[G1] |
| Authors |
Lai et al. |
| Title |
The K box, a conserved 3' UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts |
| Citation |
Development 125:4077-88 |
| Year |
1998 |
