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::General Information
ID U0025
Creation Date 22 November 2002
Updating Date 22 November 2002
Standard Name GY-Box (GY)
UTRSite Pattern
GTCTTCC
Random Expectation 0.0488070000 hits/kb
::Taxonomy
UTR Region 3'
Taxon Range Metazoa
::Description
Description Many Notch pathway target genes in Drosophila, including most members of the basic helix-loop-helix repressor family and the Bearded family, contain a series of conserved sequence motifs in their 3' UTRs, including the Brd box, the K box, and the GY box. The GY box (GTCTTCC) is present in one or more copies in several of these 3' UTRs, but does not appear to have strong cis-regulatory activity. However, its function likely involves the formation of RNA duplexes with (1) a complemen......
::Features
Feature Key GY-BOX
::Transcript(s) / Gene(s)
UTR(s)
Description Species Link Ref.
3' UTR in Drosophila melanogaster bearded (Brd), mRNA. Drosophila melanogaster UTRef: 3DMER010425 [U1]
Transcript(s)
Description Species Link Ref.
Drosophila melanogaster bearded (Brd), mRNA. Drosophila melanogaster RefSeq: NM_057541 [T1]
Gene(s)
Description Species Link Ref.
Brd Bearded. Drosophila melanogaster EntrezGene: 39620 [G1]
::References
ID [1]
Authors Lai, E. C., R. Bodner, J. Kavaler, G. Freschi, and J. W. Posakony
Title Antagonism of Notch signaling activity by members of a novel protein family encoded by the Bearded and Enhancer of split gene complexes
Citation Development 127: 291-306
Year 2000
ID [2]
Authors Lai et al.
Title The K box, a conserved 3' UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts
Citation Development 125:4077-88
Year 1998
ID [3]
Authors Lai E.C.
Title Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation
Citation Nature Genetics. 30:363-4
Year 2002
ID [U1]
Authors Lai et al.
Title The K box, a conserved 3' UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts
Citation Development 125:4077-88
Year 1998
ID [T1]
Authors Lai et al.
Title The K box, a conserved 3' UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts
Citation Development 125:4077-88
Year 1998
ID [G1]
Authors Lai et al.
Title The K box, a conserved 3' UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts
Citation Development 125:4077-88
Year 1998