| ID |
U0026 |
|
| Creation Date |
22 November 2002 |
| Updating Date |
11 August 2006 |
|
| Standard Name |
Androgen receptor CU-rich element (AR_CURE) |
| UTRSite Pattern |
p1=cuggg p2=10...40 p3=cccuccc
p2:(p4=yyyyyyyyyy)
p1/p2/p3:(c p5=uuuuuuuuuuuu[0,7,0] c)
|
| Random Expectation |
0.0 hits/kb |
|
| UTR Region |
3' |
| Taxon Range |
Metazoa |
|
| Description |
The androgen receptor mRNA contains a highly conserved UC-rich
region in the 3'-untranslated region that are the target of HuR
and CP1/CP2 RNA binding proteins imvolved in the regulation of
mRNA stability and translation initiation. Mutational analysis
has shown that HuR (also binding AU-rich motifs) binds to the U-rich
portion of the UC-rich region whereas CP1 and CP2 bind to the C-rich
portion. A model of cooperative binding of HuR and CPs is proposed
with binding disruption resulting in transcript destabilization.
|
|
|
|
| Feature Key |
AR_CURE |
|
| UTR(s) |
| Description |
Species |
Link |
Ref. |
| 3' utr in Homo sapiens androgen receptor (AR), transcript variant 1, mRNA. |
Homo sapiens |
UTRef: 3HSAR032351 |
[U1] |
|
| Transcript(s) |
| Description |
Species |
Link |
Ref. |
| Homo sapiens androgen receptor (AR), transcript variant 1, mRNA. |
Homo sapiens |
RefSeq: NM_000044 |
[T1] |
|
| Gene(s) |
|
|
| Binding Protein(s) |
| Description |
Species |
Link |
Ref. |
| Homo sapiens ELAV (embryonic lethal, abnormal vision,
Drosophila)-like 1 (Hu antigen R) (ELAVL1). |
Homo sapiens |
RefSeq: NP_001410 |
[B1] |
|
|
| ID |
[1] |
| Authors |
Yeap et al. |
| Title |
Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA |
| Citation |
J Biol Chem. 277(30):27183-92 |
| Year |
2002 |
| ID |
[U1] |
| Authors |
Yeap et al. |
| Title |
Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA |
| Citation |
J Biol Chem. 277(30):27183-92 |
| Year |
2002 |
| ID |
[T1] |
| Authors |
Yeap et al. |
| Title |
Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA |
| Citation |
J Biol Chem. 277(30):27183-92 |
| Year |
2002 |
| ID |
[G1] |
| Authors |
Yeap et al. |
| Title |
Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA |
| Citation |
J Biol Chem. 277(30):27183-92 |
| Year |
2002 |
| ID |
[B1] |
| Authors |
Yeap et al. |
| Title |
Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA |
| Citation |
J Biol Chem. 277(30):27183-92 |
| Year |
2002 |
