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::General Information
ID U0026
Creation Date 22 November 2002
Updating Date 11 August 2006
Standard Name Androgen receptor CU-rich element (AR_CURE)
UTRSite Pattern
p1=cuggg p2=10...40 p3=cccuccc
p2:(p4=yyyyyyyyyy)
p1/p2/p3:(c p5=uuuuuuuuuuuu[0,7,0] c)
Random Expectation 0.0 hits/kb
::Taxonomy
UTR Region 3'
Taxon Range Metazoa
::Description
Description The androgen receptor mRNA contains a highly conserved UC-rich region in the 3'-untranslated region that are the target of HuR and CP1/CP2 RNA binding proteins imvolved in the regulation of mRNA stability and translation initiation. Mutational analysis has shown that HuR (also binding AU-rich motifs) binds to the U-rich portion of the UC-rich region whereas CP1 and CP2 bind to the C-rich portion. A model of cooperative binding of HuR and CPs is proposed with binding disruption resu......
::Features
Feature Key AR_CURE
::Transcript(s) / Gene(s)
UTR(s)
Description Species Link Ref.
3' utr in Homo sapiens androgen receptor (AR), transcript variant 1, mRNA. Homo sapiens UTRef: 3HSAR032351 [U1]
Transcript(s)
Description Species Link Ref.
Homo sapiens androgen receptor (AR), transcript variant 1, mRNA. Homo sapiens RefSeq: NM_000044 [T1]
Gene(s)
Description Species Link Ref.
androgen receptor (AR). Homo sapiens EntrezGene: 367 [G1]
::Protein(s)
Binding Protein(s)
Description Species Link Ref.
Homo sapiens ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) (ELAVL1). Homo sapiens RefSeq: NP_001410 [B1]
::References
ID [1]
Authors Yeap et al.
Title Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA
Citation J Biol Chem. 277(30):27183-92
Year 2002
ID [U1]
Authors Yeap et al.
Title Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA
Citation J Biol Chem. 277(30):27183-92
Year 2002
ID [T1]
Authors Yeap et al.
Title Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA
Citation J Biol Chem. 277(30):27183-92
Year 2002
ID [G1]
Authors Yeap et al.
Title Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA
Citation J Biol Chem. 277(30):27183-92
Year 2002
ID [B1]
Authors Yeap et al.
Title Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA
Citation J Biol Chem. 277(30):27183-92
Year 2002