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References
UTRdb and UTRsite (RELEASE 2010): a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs.
Nucleic Acids Res. 2010; 38 (Database issue): D75-D80.

UTRdb and UTRsite: a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs.
Nucleic Acids Res. 2005 Jan 1; 33 (Database issue): D141-6.

UTRdb and UTRsite: specialized databases of sequences and functional elements of 5' and 3' untranslated regions of eukaryotic mRNAs. Update 2002.
Nucleic Acids Res. 2002 Jan 1; 30 (1): 335-40.

UTRdb and UTRsite: specialized databases of sequences and functional elements of 5' and 3' untranslated regions of eukaryotic mRNAs.
Nucleic Acids Res. 2000 Jan 1; 28 (1): 193-6

Signal Manager :: View

::General Information
ID U0027
Creation Date 15 July 2003
Updating Date 15 July 2003
Standard Name Elastin G3A 3'UTR stability motif (G3A)
UTRSite Pattern
tgnn p1=rrrrrrrrrrrrrrrrrrr[1,3,0]
p1:(ggga ggga 0...3 ggga 0...1 ggg)
Random Expectation 0.0 hits/kb
::Taxonomy
UTR Region 3'
Taxon Range Vertebrata
::Description
Description Developmental regulation of elastin synthesis occurs through modulation of the stability of its mRNA. It has been demonstrated that the binding of cytosolic proteins to a large region of the 3'UTR of elastin mRNA, possibly folded into a stable secondary structure, is associated to stabilization/destabilization of elastin mRNA. Using deletion and competition analyses the core cis-acting sequence has been mapped to a 20 nt long purine rich sequence containing at least a 3-fold repeat of GGGA (G3A) motif conserved from human to chicken.
::Features
Feature Key G3A
::Transcript(s) / Gene(s)
UTR(s)
Description Species Link Ref.
3' UTR in Homo sapiens elastin (ELN), transcript variant 1, mRNA. Homo sapiens UTRef: 3HSAR026996 [U1]
Transcript(s)
Description Species Link Ref.
Homo sapiens elastin (ELN), transcript variant 1, mRNA. Homo sapiens RefSeq: NM_000501 [T1]
Gene(s)
Description Species Link Ref.
elastin (ELN). Homo sapiens EntrezGene: 2006 [G1]
::References
ID [1]
Authors Hew Y, Lau C, Grzelczak Z, Keeley FW
Title Identification of a GA-rich sequence as a protein-binding site in the 3'-untranslated region of chicken elastin mRNA with a potential role in the developmental regulation of elastin mRNA stability
Citation J Biol Chem. (2000) 275(32):24857-64
Year 2000
ID [U1]
Authors Hew Y, Lau C, Grzelczak Z, Keeley FW
Title Identification of a GA-rich sequence as a protein-binding site in the 3'-untranslated region of chicken elastin mRNA with a potential role in the developmental regulation of elastin mRNA stability
Citation J Biol Chem. (2000) 275(32):24857-64
Year 2000
ID [T1]
Authors Hew Y, Lau C, Grzelczak Z, Keeley FW
Title Identification of a GA-rich sequence as a protein-binding site in the 3'-untranslated region of chicken elastin mRNA with a potential role in the developmental regulation of elastin mRNA stability
Citation J Biol Chem. (2000) 275(32):24857-64
Year 2000
ID [G1]
Authors Hew Y, Lau C, Grzelczak Z, Keeley FW
Title Identification of a GA-rich sequence as a protein-binding site in the 3'-untranslated region of chicken elastin mRNA with a potential role in the developmental regulation of elastin mRNA stability
Citation J Biol Chem. (2000) 275(32):24857-64
Year 2000
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