| ID |
U0027 |
|
| Creation Date |
15 July 2003 |
| Updating Date |
15 July 2003 |
|
| Standard Name |
Elastin G3A 3'UTR stability motif (G3A) |
| UTRSite Pattern |
tgnn p1=rrrrrrrrrrrrrrrrrrr[1,3,0]
p1:(ggga ggga 0...3 ggga 0...1 ggg)
|
| Random Expectation |
0.0 hits/kb |
|
| UTR Region |
3' |
| Taxon Range |
Vertebrata |
|
| Description |
Developmental regulation of elastin synthesis occurs through modulation
of the stability of its mRNA. It has been demonstrated that the binding
of cytosolic proteins to a large region of the 3'UTR of elastin mRNA,
possibly folded into a stable secondary structure, is associated to
stabilization/destabilization of elastin mRNA. Using deletion and
competition analyses the core cis-acting sequence has been mapped to
a 20 nt long purine rich sequence containing at least a 3-fold repeat
of GGGA (G3A) motif conserved from human to chicken. |
|
|
|
| Feature Key |
G3A |
|
| UTR(s) |
| Description |
Species |
Link |
Ref. |
| 3' UTR in Homo sapiens elastin (ELN), transcript variant 1, mRNA. |
Homo sapiens |
UTRef: 3HSAR026996 |
[U1] |
|
| Transcript(s) |
| Description |
Species |
Link |
Ref. |
| Homo sapiens elastin (ELN), transcript variant 1, mRNA. |
Homo sapiens |
RefSeq: NM_000501 |
[T1] |
|
| Gene(s) |
|
|
| ID |
[1] |
| Authors |
Hew Y, Lau C, Grzelczak Z, Keeley FW |
| Title |
Identification of a GA-rich sequence as a protein-binding site in the 3'-untranslated region of chicken elastin mRNA with a potential role in the developmental regulation of elastin mRNA stability |
| Citation |
J Biol Chem. (2000) 275(32):24857-64 |
| Year |
2000 |
| ID |
[U1] |
| Authors |
Hew Y, Lau C, Grzelczak Z, Keeley FW |
| Title |
Identification of a GA-rich sequence as a protein-binding site in the 3'-untranslated region of chicken elastin mRNA with a potential role in the developmental regulation of elastin mRNA stability |
| Citation |
J Biol Chem. (2000) 275(32):24857-64 |
| Year |
2000 |
| ID |
[T1] |
| Authors |
Hew Y, Lau C, Grzelczak Z, Keeley FW |
| Title |
Identification of a GA-rich sequence as a protein-binding site in the 3'-untranslated region of chicken elastin mRNA with a potential role in the developmental regulation of elastin mRNA stability |
| Citation |
J Biol Chem. (2000) 275(32):24857-64 |
| Year |
2000 |
| ID |
[G1] |
| Authors |
Hew Y, Lau C, Grzelczak Z, Keeley FW |
| Title |
Identification of a GA-rich sequence as a protein-binding site in the 3'-untranslated region of chicken elastin mRNA with a potential role in the developmental regulation of elastin mRNA stability |
| Citation |
J Biol Chem. (2000) 275(32):24857-64 |
| Year |
2000 |
