ID |
U0028 |
Creation Date |
23 July 2003 |
Updating Date |
23 July 2003 |
Standard Name |
Insulin 3'UTR stability element (INS_SCE) |
UTRSite Pattern |
p1=3...7 p1:(p3=RCC) p2=YCCYRCCCNCC[3,0,0] p2:(p4=NNCNRNNCNNN) 0...3 ((CC|AC)|CT)
0...3 TGSM 1...13 AATAAA
|
Random Expectation |
0.0000402334 hits/kb |
UTR Region |
3' |
Taxon Range |
Metazoa |
Description |
Stabilization of insulin mRNA in response to glucose is a key
modulator of insulin production. Experimental data suggest that
insulin mRNA stability is controlled by the binding of a 55-60 kDa
protein to a pyrimidine-rich sequence (PRS) located in the 3'UTR
of insulin mRNA. The binding of this protein, probably the polypirimidine
tract-binding protein (PTB), is stimulated by reducing agents (e.g. DTT)
and glucose. Mutation of the core PSR sequence, present in human and
rodent but not all mammal insulin mRNAs, prevents protein binding and
results in transcripts destabilization. |
|
Feature Key |
INS_SCE |
UTR(s) |
Description |
Species |
Link |
Ref. |
3' UTR in Rattus norvegicus insulin 1 (Ins1), mRNA. |
Rattus norvegicus |
UTRef: 3RNOR019497 |
[U1] |
|
Transcript(s) |
Description |
Species |
Link |
Ref. |
Rattus norvegicus insulin 1 (Ins1), mRNA. |
Rattus norvegicus |
RefSeq: NM_019129 |
[T1] |
|
Gene(s) |
|
Binding Protein(s) |
Description |
Species |
Link |
Ref. |
polypyrimidine tract binding protein 1 isoform b. |
Rattus norvegicus |
RefSeq: NP_071961 |
[B1] |
|
ID |
[1] |
Authors |
Tillmar L, Carlsson C, Welsh N. |
Title |
Control of insulin mRNA stability in rat pancreatic islets. Regulatory role of a 3'-untranslated region pyrimidine-rich sequence |
Citation |
J Biol Chem. (2002) 277(2):1099-106 |
Year |
2002 |
ID |
[U1] |
Authors |
Tillmar L, Carlsson C, Welsh N. |
Title |
Control of insulin mRNA stability in rat pancreatic islets. Regulatory role of a 3'-untranslated region pyrimidine-rich sequence |
Citation |
J Biol Chem. (2002) 277(2):1099-106 |
Year |
2002 |
ID |
[T1] |
Authors |
Tillmar L, Carlsson C, Welsh N. |
Title |
Control of insulin mRNA stability in rat pancreatic islets. Regulatory role of a 3'-untranslated region pyrimidine-rich sequence |
Citation |
J Biol Chem. (2002) 277(2):1099-106 |
Year |
2002 |
ID |
[G1] |
Authors |
Tillmar L, Carlsson C, Welsh N. |
Title |
Control of insulin mRNA stability in rat pancreatic islets. Regulatory role of a 3'-untranslated region pyrimidine-rich sequence |
Citation |
J Biol Chem. (2002) 277(2):1099-106 |
Year |
2002 |
ID |
[B1] |
Authors |
Tillmar L, Carlsson C, Welsh N. |
Title |
Control of insulin mRNA stability in rat pancreatic islets. Regulatory role of a 3'-untranslated region pyrimidine-rich sequence |
Citation |
J Biol Chem. (2002) 277(2):1099-106 |
Year |
2002 |