Signal Manager :: View

::General Information

ID U0028

Creation Date 23 July 2003

Updating Date 23 July 2003

Standard Name Insulin 3'UTR stability element (INS_SCE)

UTRSite Pattern

p1=3...7 p1:(p3=RCC) p2=YCCYRCCCNCC[3,0,0] p2:(p4=NNCNRNNCNNN) 0...3 ((CC|AC)|CT)
0...3 TGSM 1...13 AATAAA

Random Expectation 0.0000402334 hits/kb

::Taxonomy

UTR Region 3'

Taxon Range Metazoa

::Description

Description Stabilization of insulin mRNA in response to glucose is a key modulator of insulin production. Experimental data suggest that insulin mRNA stability is controlled by the binding of a 55-60 kDa protein to a pyrimidine-rich sequence (PRS) located in the 3'UTR of insulin mRNA. The binding of this protein, probably the polypirimidine tract-binding protein (PTB), is stimulated by reducing agents (e.g. DTT) and glucose. Mutation of the core PSR sequence, present in human and rodent but not all mammal insulin mRNAs, prevents protein binding and results in transcripts destabilization.

::Features

Feature Key INS_SCE

::Transcript(s) / Gene(s)

UTR(s)

Description	Species	Link	Ref.
3' UTR in Rattus norvegicus insulin 1 (Ins1), mRNA.	Rattus norvegicus	UTRef: 3RNOR019497	[U1]

Transcript(s)

Description	Species	Link	Ref.
Rattus norvegicus insulin 1 (Ins1), mRNA.	Rattus norvegicus	RefSeq: NM_019129	[T1]

Gene(s)

Description	Species	Link	Ref.
insulin 1 (Ins1).	Rattus norvegicus	EntrezGene: 24505	[G1]

::Protein(s)

Binding Protein(s)

Description	Species	Link	Ref.
polypyrimidine tract binding protein 1 isoform b.	Rattus norvegicus	RefSeq: NP_071961	[B1]

::References

ID [1]