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::General Information
ID U0028
Creation Date 23 July 2003
Updating Date 23 July 2003
Standard Name Insulin 3'UTR stability element (INS_SCE)
UTRSite Pattern
p1=3...7 p1:(p3=RCC) p2=YCCYRCCCNCC[3,0,0] p2:(p4=NNCNRNNCNNN) 0...3 ((CC|AC)|CT)
0...3 TGSM 1...13 AATAAA
Random Expectation 0.0000402334 hits/kb
::Taxonomy
UTR Region 3'
Taxon Range Metazoa
::Description
Description Stabilization of insulin mRNA in response to glucose is a key modulator of insulin production. Experimental data suggest that insulin mRNA stability is controlled by the binding of a 55-60 kDa protein to a pyrimidine-rich sequence (PRS) located in the 3'UTR of insulin mRNA. The binding of this protein, probably the polypirimidine tract-binding protein (PTB), is stimulated by reducing agents (e.g. DTT) and glucose. Mutation of the core PSR sequence, present in human and rodent but not all mammal insulin mRNAs, prevents protein binding and results in transcripts destabilization.
::Features
Feature Key INS_SCE
::Transcript(s) / Gene(s)
UTR(s)
Description Species Link Ref.
3' UTR in Rattus norvegicus insulin 1 (Ins1), mRNA. Rattus norvegicus UTRef: 3RNOR019497 [U1]
Transcript(s)
Description Species Link Ref.
Rattus norvegicus insulin 1 (Ins1), mRNA. Rattus norvegicus RefSeq: NM_019129 [T1]
Gene(s)
Description Species Link Ref.
insulin 1 (Ins1). Rattus norvegicus EntrezGene: 24505 [G1]
::Protein(s)
Binding Protein(s)
Description Species Link Ref.
polypyrimidine tract binding protein 1 isoform b. Rattus norvegicus RefSeq: NP_071961 [B1]
::References
ID [1]
Authors Tillmar L, Carlsson C, Welsh N.
Title Control of insulin mRNA stability in rat pancreatic islets. Regulatory role of a 3'-untranslated region pyrimidine-rich sequence
Citation J Biol Chem. (2002) 277(2):1099-106
Year 2002
ID [U1]
Authors Tillmar L, Carlsson C, Welsh N.
Title Control of insulin mRNA stability in rat pancreatic islets. Regulatory role of a 3'-untranslated region pyrimidine-rich sequence
Citation J Biol Chem. (2002) 277(2):1099-106
Year 2002
ID [T1]
Authors Tillmar L, Carlsson C, Welsh N.
Title Control of insulin mRNA stability in rat pancreatic islets. Regulatory role of a 3'-untranslated region pyrimidine-rich sequence
Citation J Biol Chem. (2002) 277(2):1099-106
Year 2002
ID [G1]
Authors Tillmar L, Carlsson C, Welsh N.
Title Control of insulin mRNA stability in rat pancreatic islets. Regulatory role of a 3'-untranslated region pyrimidine-rich sequence
Citation J Biol Chem. (2002) 277(2):1099-106
Year 2002
ID [B1]
Authors Tillmar L, Carlsson C, Welsh N.
Title Control of insulin mRNA stability in rat pancreatic islets. Regulatory role of a 3'-untranslated region pyrimidine-rich sequence
Citation J Biol Chem. (2002) 277(2):1099-106
Year 2002