Signal Manager :: View

::General Information

ID U0028

Creation Date 23 July 2003

Updating Date 23 July 2003

Standard Name Insulin 3'UTR stability element (INS_SCE)

UTRSite Pattern

p1=3...7 p1:(p3=RCC) p2=YCCYRCCCNCC[3,0,0] p2:(p4=NNCNRNNCNNN) 0...3 ((CC|AC)|CT)
0...3 TGSM 1...13 AATAAA

Random Expectation 0.0000402334 hits/kb

::Taxonomy

UTR Region 3'

Taxon Range Metazoa

::Description

Description Stabilization of insulin mRNA in response to glucose is a key modulator of insulin production. Experimental data suggest that insulin mRNA stability is controlled by the binding of a 55-60 kDa protein to a pyrimidine-rich sequence (PRS) located in the 3'UTR of insulin mRNA. The binding of this protein, probably the polypirimidine tract-binding protein (PTB), is stimulated by reducing agents (e.g. DTT) and glucose. Mutation of the core PSR sequence, present in human and rodent bu......

::Features

Feature Key INS_SCE

::Transcript(s) / Gene(s)

UTR(s)

Description	Species	Link	Ref.
3' UTR in Rattus norvegicus insulin 1 (Ins1), mRNA.	Rattus norvegicus	UTRef: 3RNOR019497	[U1]

Transcript(s)

Description	Species	Link	Ref.
Rattus norvegicus insulin 1 (Ins1), mRNA.	Rattus norvegicus	RefSeq: NM_019129	[T1]

Gene(s)

Description	Species	Link	Ref.
insulin 1 (Ins1).	Rattus norvegicus	EntrezGene: 24505	[G1]

::Protein(s)

Binding Protein(s)

Description	Species	Link	Ref.
polypyrimidine tract binding protein 1 isoform b.	Rattus norvegicus	RefSeq: NP_071961	[B1]

::References

ID [1]