| ID |
U0030 |
|
| Creation Date |
23 July 2003 |
| Updating Date |
23 July 2003 |
|
| Standard Name |
Gap-43 Stabilization Element (GAP-43) |
| UTRSite Pattern |
guccacuuuccu yyyyyy[0,6,0] muyucucucug
|
| Random Expectation |
0.0 hits/kb |
|
| UTR Region |
3' |
| Taxon Range |
Metazoa |
|
| Description |
The expression of Growth Associated Protein (GAP-43)
involved in neurite outgrowth is post-trascriptionally regulated by a
highly conserved 23-29 nt long sequence in the mRNA 3'UTR. The
interaction of this element with the ELAV-like RNA binding protein
HuD results in the increased stability of gap-43 transcript.
|
|
|
|
| Feature Key |
GAP-43 |
|
| UTR(s) |
| Description |
Species |
Link |
Ref. |
| 3' UTR in Rattus norvegicus growth associated protein 43 (Gap43), mRNA. |
Rattus norvegicus |
UTRef: 3RNOR014867 |
[U1] |
|
| Transcript(s) |
| Description |
Species |
Link |
Ref. |
| Rattus norvegicus growth associated protein 43 (Gap43), mRNA. |
Rattus norvegicus |
RefSeq: NM_017195 |
[T1] |
|
| Gene(s) |
| Description |
Species |
Link |
Ref. |
| Gap43 growth associated protein 43. |
Rattus norvegicus |
EntrezGene: 29423 |
[G1] |
|
|
| Binding Protein(s) |
|
|
| ID |
[1] |
| Authors |
Chung S, Eckrich M, Perrone-Bizzozero N, Kohn DT, and Furneaux H |
| Title |
Elav-like Proteins Bind to a Conserved Regulatory Element in the 3�-Untranslated Region of GAP-43 mRNA |
| Citation |
J. Biol. Chem. (1997) 272: 6593�6598 |
| Year |
1997 |
| ID |
[2] |
| Authors |
Kohn DT, Tsai K-C, Canino VV, Neve RL and Perrone-Bizzozero N. |
| Title |
Role of highly conserved pyrimidine-rich sequences in the 3�untranslated region of the GAP-43 mRNA in mRNA stability and RNA-protein interactions |
| Citation |
Mol. Brain Res. (1996) 36: 240-250 |
| Year |
1996 |
| ID |
[U1] |
| Authors |
Kohn DT, Tsai K-C, Canino VV, Neve RL and Perrone-Bizzozero N. |
| Title |
Role of highly conserved pyrimidine-rich sequences in the 3�untranslated region of the GAP-43 mRNA in mRNA stability and RNA-protein interactions |
| Citation |
Mol. Brain Res. (1996) 36: 240-250 |
| Year |
1996 |
| ID |
[T1] |
| Authors |
Kohn DT, Tsai K-C, Canino VV, Neve RL and Perrone-Bizzozero N. |
| Title |
Role of highly conserved pyrimidine-rich sequences in the 3�untranslated region of the GAP-43 mRNA in mRNA stability and RNA-protein interactions |
| Citation |
Mol. Brain Res. (1996) 36: 240-250 |
| Year |
1996 |
| ID |
[G1] |
| Authors |
Kohn DT, Tsai K-C, Canino VV, Neve RL and Perrone-Bizzozero N. |
| Title |
Role of highly conserved pyrimidine-rich sequences in the 3�untranslated region of the GAP-43 mRNA in mRNA stability and RNA-protein interactions |
| Citation |
Mol. Brain Res. (1996) 36: 240-250 |
| Year |
1996 |
| ID |
[B1] |
| Authors |
Chung S, Eckrich M, Perrone-Bizzozero N, Kohn DT, and Furneaux H |
| Title |
Elav-like Proteins Bind to a Conserved Regulatory Element in the 3�-Untranslated Region of GAP-43 mRNA |
| Citation |
J. Biol. Chem. (1997) 272: 6593�6598 |
| Year |
1997 |
