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::General Information
ID U0030
Creation Date 23 July 2003
Updating Date 23 July 2003
Standard Name Gap-43 Stabilization Element (GAP-43)
UTRSite Pattern
guccacuuuccu yyyyyy[0,6,0] muyucucucug
Random Expectation 0.0 hits/kb
::Taxonomy
UTR Region 3'
Taxon Range Metazoa
::Description
Description The expression of Growth Associated Protein (GAP-43) involved in neurite outgrowth is post-trascriptionally regulated by a highly conserved 23-29 nt long sequence in the mRNA 3'UTR. The interaction of this element with the ELAV-like RNA binding protein HuD results in the increased stability of gap-43 transcript.
::Features
Feature Key GAP-43
::Transcript(s) / Gene(s)
UTR(s)
Description Species Link Ref.
3' UTR in Rattus norvegicus growth associated protein 43 (Gap43), mRNA. Rattus norvegicus UTRef: 3RNOR014867 [U1]
Transcript(s)
Description Species Link Ref.
Rattus norvegicus growth associated protein 43 (Gap43), mRNA. Rattus norvegicus RefSeq: NM_017195 [T1]
Gene(s)
Description Species Link Ref.
Gap43 growth associated protein 43. Rattus norvegicus EntrezGene: 29423 [G1]
::Protein(s)
Binding Protein(s)
Description Species Link Ref.
RNA-binding protein HuC. Rattus norvegicus RefSeq: NP_990163 [B1]
::References
ID [1]
Authors Chung S, Eckrich M, Perrone-Bizzozero N, Kohn DT, and Furneaux H
Title Elav-like Proteins Bind to a Conserved Regulatory Element in the 3�-Untranslated Region of GAP-43 mRNA
Citation J. Biol. Chem. (1997) 272: 6593�6598
Year 1997
ID [2]
Authors Kohn DT, Tsai K-C, Canino VV, Neve RL and Perrone-Bizzozero N.
Title Role of highly conserved pyrimidine-rich sequences in the 3�untranslated region of the GAP-43 mRNA in mRNA stability and RNA-protein interactions
Citation Mol. Brain Res. (1996) 36: 240-250
Year 1996
ID [U1]
Authors Kohn DT, Tsai K-C, Canino VV, Neve RL and Perrone-Bizzozero N.
Title Role of highly conserved pyrimidine-rich sequences in the 3�untranslated region of the GAP-43 mRNA in mRNA stability and RNA-protein interactions
Citation Mol. Brain Res. (1996) 36: 240-250
Year 1996
ID [T1]
Authors Kohn DT, Tsai K-C, Canino VV, Neve RL and Perrone-Bizzozero N.
Title Role of highly conserved pyrimidine-rich sequences in the 3�untranslated region of the GAP-43 mRNA in mRNA stability and RNA-protein interactions
Citation Mol. Brain Res. (1996) 36: 240-250
Year 1996
ID [G1]
Authors Kohn DT, Tsai K-C, Canino VV, Neve RL and Perrone-Bizzozero N.
Title Role of highly conserved pyrimidine-rich sequences in the 3�untranslated region of the GAP-43 mRNA in mRNA stability and RNA-protein interactions
Citation Mol. Brain Res. (1996) 36: 240-250
Year 1996
ID [B1]
Authors Chung S, Eckrich M, Perrone-Bizzozero N, Kohn DT, and Furneaux H
Title Elav-like Proteins Bind to a Conserved Regulatory Element in the 3�-Untranslated Region of GAP-43 mRNA
Citation J. Biol. Chem. (1997) 272: 6593�6598
Year 1997