| ID |
U0031 |
|
| Creation Date |
23 July 2003 |
| Updating Date |
23 July 2003 |
|
| Standard Name |
CaMKII/Ng dendritic localization element (CNDLE) |
| UTRSite Pattern |
yrggrnc 0...4 cs 6...10 cscagaga 0...1 tcc 0...1 ytcw 2...8 wgg
|
|
| UTR Region |
3' |
| Taxon Range |
Metazoa |
|
| Description |
Alpha subunit of calcium calmodulin dependent kinase II (CaMKII)
protein, highly enriched at synapse is important in synaptic plasticity, learning and long-term memory. The 5' part (nt 1-94) of 3'UTR of CaMKII
mRNA mediates its dendritic targeting.
An inhibitory element located downstream in the 3'UTR prevents CaMKII
mRNA transport into dendrites.
Prolonged depolarization override transport repression thus suggesting an
anctivity-sensitive interaction between the two control elements.
A similar dendritic localization element has been found to be active in
the 3'UTR of neurogranin (Ng) mRNA, coding for a neuronal specific calmodulin
binding protein. The minimal targeting signal denoted as CaMKII/Ng dendritic
localization element (CNDLE) corresponds to a highly conserved 28-nt region.
|
|
|
|
| Feature Key |
CNDLE |
|
| UTR(s) |
| Description |
Species |
Link |
Ref. |
| 3' UTR in Homo sapiens calcium/calmodulin-dependent protein kinase II alpha (CAMK2A), transcript variant 1, mRNA. |
Homo sapiens |
UTRef: 3HSAR030067 |
[U1] |
|
| Transcript(s) |
| Description |
Species |
Link |
Ref. |
| Homo sapiens calcium/calmodulin-dependent protein kinase II alpha (CAMK2A), transcript variant 1, mRNA. |
Homo sapiens |
RefSeq: NM_015981 |
[T1] |
|
| Gene(s) |
| Description |
Species |
Link |
Ref. |
| CAMK2A calcium/calmodulin-dependent protein kinase II alpha. |
Homo sapiens |
EntrezGene: 815 |
[G1] |
|
|
| ID |
[1] |
| Authors |
Mori Y, Imaizumi K, Katayama T, Yoneda T and Tohyama M. |
| Title |
Two cis-acting elements in the 3�untranslated region of alpha-CaMKII regulate its dendritic targeting |
| Citation |
Nature Neuroscience (2000) 3: 1079-1084 |
| Year |
2000 |
| ID |
[U1] |
| Authors |
Mori Y, Imaizumi K, Katayama T, Yoneda T and Tohyama M. |
| Title |
Two cis-acting elements in the 3�untranslated region of alpha-CaMKII regulate its dendritic targeting |
| Citation |
Nature Neuroscience (2000) 3: 1079-1084 |
| Year |
2000 |
| ID |
[T1] |
| Authors |
Mori Y, Imaizumi K, Katayama T, Yoneda T and Tohyama M. |
| Title |
Two cis-acting elements in the 3�untranslated region of alpha-CaMKII regulate its dendritic targeting |
| Citation |
Nature Neuroscience (2000) 3: 1079-1084 |
| Year |
2000 |
| ID |
[G1] |
| Authors |
Mori Y, Imaizumi K, Katayama T, Yoneda T and Tohyama M. |
| Title |
Two cis-acting elements in the 3�untranslated region of alpha-CaMKII regulate its dendritic targeting |
| Citation |
Nature Neuroscience (2000) 3: 1079-1084 |
| Year |
2000 |
