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References
UTRdb and UTRsite (RELEASE 2010): a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs.
Nucleic Acids Res. 2010; 38 (Database issue): D75-D80.

UTRdb and UTRsite: a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs.
Nucleic Acids Res. 2005 Jan 1; 33 (Database issue): D141-6.

UTRdb and UTRsite: specialized databases of sequences and functional elements of 5' and 3' untranslated regions of eukaryotic mRNAs. Update 2002.
Nucleic Acids Res. 2002 Jan 1; 30 (1): 335-40.

UTRdb and UTRsite: specialized databases of sequences and functional elements of 5' and 3' untranslated regions of eukaryotic mRNAs.
Nucleic Acids Res. 2000 Jan 1; 28 (1): 193-6

Signal Manager :: View

::General Information
ID U0031
Creation Date 23 July 2003
Updating Date 23 July 2003
Standard Name CaMKII/Ng dendritic localization element (CNDLE)
UTRSite Pattern
yrggrnc 0...4 cs 6...10 cscagaga 0...1 tcc 0...1 ytcw 2...8 wgg
::Taxonomy
UTR Region 3'
Taxon Range Metazoa
::Description
Description Alpha subunit of calcium calmodulin dependent kinase II (CaMKII) protein, highly enriched at synapse is important in synaptic plasticity, learning and long-term memory. The 5' part (nt 1-94) of 3'UTR of CaMKII mRNA mediates its dendritic targeting. An inhibitory element located downstream in the 3'UTR prevents CaMKII mRNA transport into dendrites. Prolonged depolarization override transport repression thus suggesting an anctivity-sensitive interaction between the two control elements. A similar dendritic localization element has been found to be active in the 3'UTR of neurogranin (Ng) mRNA, coding for a neuronal specific calmodulin binding protein. The minimal targeting signal denoted as CaMKII/Ng dendritic localization element (CNDLE) corresponds to a highly conserved 28-nt region.
::Features
Feature Key CNDLE
::Transcript(s) / Gene(s)
UTR(s)
Description Species Link Ref.
3' UTR in Homo sapiens calcium/calmodulin-dependent protein kinase II alpha (CAMK2A), transcript variant 1, mRNA. Homo sapiens UTRef: 3HSAR030067 [U1]
Transcript(s)
Description Species Link Ref.
Homo sapiens calcium/calmodulin-dependent protein kinase II alpha (CAMK2A), transcript variant 1, mRNA. Homo sapiens RefSeq: NM_015981 [T1]
Gene(s)
Description Species Link Ref.
CAMK2A calcium/calmodulin-dependent protein kinase II alpha. Homo sapiens EntrezGene: 815 [G1]
::References
ID [1]
Authors Mori Y, Imaizumi K, Katayama T, Yoneda T and Tohyama M.
Title Two cis-acting elements in the 3�untranslated region of alpha-CaMKII regulate its dendritic targeting
Citation Nature Neuroscience (2000) 3: 1079-1084
Year 2000
ID [U1]
Authors Mori Y, Imaizumi K, Katayama T, Yoneda T and Tohyama M.
Title Two cis-acting elements in the 3�untranslated region of alpha-CaMKII regulate its dendritic targeting
Citation Nature Neuroscience (2000) 3: 1079-1084
Year 2000
ID [T1]
Authors Mori Y, Imaizumi K, Katayama T, Yoneda T and Tohyama M.
Title Two cis-acting elements in the 3�untranslated region of alpha-CaMKII regulate its dendritic targeting
Citation Nature Neuroscience (2000) 3: 1079-1084
Year 2000
ID [G1]
Authors Mori Y, Imaizumi K, Katayama T, Yoneda T and Tohyama M.
Title Two cis-acting elements in the 3�untranslated region of alpha-CaMKII regulate its dendritic targeting
Citation Nature Neuroscience (2000) 3: 1079-1084
Year 2000
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