UTRSite Logo
user: guest

Signal Manager :: View

::General Information
ID U0034
Creation Date 27 July 2004
Updating Date 28 September 2009
Standard Name Gamma interferon activated inhibitor of translation (GAIT element)
UTRSite Pattern
AANGNUUACUUUGGAAUGRCUAUAMNCRUU[1,1,1]
::Taxonomy
UTR Region 3'
Taxon Range Metazoa
::Description
Description Delayed translational silencing of ceruloplasmin (Cp) mRNA by gamma-interferon (IFN-gamma) is directed by a structural element in its 3' untranslated region (Mazumder, 1999). Translational silencing requires the binding of a cytosolic inhibitor to the Cp 3'UTR and all essential elements of mRNA circularization, i.e. eukaryotic initiation factor 4G, poly-A binding protein and poly-A tail (Mazumder, 2001;? Mazumder, Seshadri, Fox, 2003). The 29-nt structural element, denoted as IFN-gamma-ac......
::Features
Feature Key GAIT
::Database Cross-references
Link
RFAM: RF00179
::Transcript(s) / Gene(s)
UTR(s)
Description Species Link Ref.
3' UTR in Homo sapiens ceruloplasmin (ferroxidase) (CP), mRNA UTRef: 3HSAR033294
Transcript(s)
Description Species Link Ref.
Homo sapiens ceruloplasmin (ferroxidase) (CP), mRNA Homo sapiens RefSeq: NM_000096
Gene(s)
Description Species Link Ref.
ceruloplasmin (ferroxidase) CP Homo sapiens ENSEMBL: ENSG00000047457
::Protein(s)
Binding Protein(s)
Description Species Link Ref.
Glutamyl-prolyl tRNA synthetase Homo sapiens UniProt: P07814 [B1]
Interactor(s) of Binding Protein(s)
Description Species Link Ref.
Glyceraldehyde-3-phosphate dehydrogenase Homo sapiens UniProt: P04406 [P1]
NS1-associated protein 1 Homo sapiens UniProt: AAD38198 [P2]
Ribosomal protein L13a Homo sapiens UniProt: NP_036555 [P3][P4]
::References
ID [1]
Authors Sampath P, Mazumder B, Seshadri V, Fox PL.
Title Transcript-selective translational silencing by gamma interferon is directed by a novel structural element in the ceruloplasmin mRNA 3' untranslated region.
Citation Mol. Cell. Biol. 23:1509-19.
Year 2003
ID [2]
Authors Mazumder B, Fox PL
Title Delayed translational silencing of ceruloplasmin transcript in gamma interferon-activated U937 monocytic cells: Role of the 3' untranslated region
Citation Mol. Cell. Biol. 19:6898-6905.
Year 1999
ID [3]
Authors Mazumder B, Seshadri V, Imataka H, Sonenberg N, Fox PL
Title Translational silencing of cerulo-plasmin requires the essential elements of mRNA circularization: Poly(A) tail, poly(A)-binding protein, and eukaryotic translation initiation factor 4G
Citation Mol. Cell. Biol. 21:6440-9.
Year 2001
ID [4]
Authors Mazumder B, Seshadri V, Fox PL
Title Translational control by the 3'-UTR: the ends specify the means
Citation Trends Biochem. Sci. 28:91-8.
Year 2003
ID [5]
Authors Mazumder B, Sampath P, Seshadri V, Maitra RK, DiCorleto PE, Fox PL.
Title Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control
Citation Cell 115:187-98.
Year 2003
ID [6]
Authors Sampath P, Mazumder B, Seshadri V, Gerber CA, Chavatte L, Kinter M, Ting SM, Dignam JD, Kim S, Driscoll DM, Fox PL
Title Noncanonical function of glutamyl-prolyl-tRNA synthetase: Gene-specific silencing of translation
Citation Cell 119:195-208.
Year 2004
ID [B1]
Authors Sampath P, Mazumder B, Seshadri V, Gerber CA, Chavatte L, Kinter M, Ting SM, Dignam JD, Kim S, Driscoll DM, Fox PL
Title Noncanonical function of glutamyl-prolyl-tRNA synthetase: Gene-specific silencing of translation
Citation Cell 119:195-208.
Year 2004
ID [P1]
Authors Sampath P, Mazumder B, Seshadri V, Gerber CA, Chavatte L, Kinter M, Ting SM, Dignam JD, Kim S, Driscoll DM, Fox PL
Title Noncanonical function of glutamyl-prolyl-tRNA synthetase: Gene-specific silencing of translation
Citation Cell 119:195-208.
Year 2004
ID [P2]
Authors Sampath P, Mazumder B, Seshadri V, Gerber CA, Chavatte L, Kinter M, Ting SM, Dignam JD, Kim S, Driscoll DM, Fox PL
Title Noncanonical function of glutamyl-prolyl-tRNA synthetase: Gene-specific silencing of translation
Citation Cell 119:195-208.
Year 2004
ID [P3]
Authors Mazumder B, Sampath P, Seshadri V, Maitra RK, DiCorleto PE, Fox PL.
Title Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control
Citation Cell 115:187-98.
Year 2003
ID [P4]
Authors Sampath P, Mazumder B, Seshadri V, Gerber CA, Chavatte L, Kinter M, Ting SM, Dignam JD, Kim S, Driscoll DM, Fox PL
Title Noncanonical function of glutamyl-prolyl-tRNA synthetase: Gene-specific silencing of translation
Citation Cell 119:195-208.
Year 2004