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::General Information
ID U0035
Creation Date 27 July 2004
Updating Date 27 January 2010
Standard Name Musashi binding element (MBE)
UTRSite Pattern
R UUU[0,2,0] AGU
Random Expectation 0.0118932000 hits/kb
::Taxonomy
UTR Region 3'
Taxon Range Metazoa
::Description
Description During progesterone-stimulated Xenopus oocyte maturation, certain pre-existing (maternal) mRNAs are selectively translated in a strict temporal order. The early translational activation of the Mos mRNA requires a Musashi binding element (MBE) that is located in the Mos 3’ untranslated region (UTR). The MBE lies within a 24 nt region originally termed a polyadenylation response element (PRE), but further analyses demonstrated that the MBE within this sequence was critical for temporal regulation (Charlesworth et.al., 2002; Charlesworth et.al., 2006). The MBE consensus sequence (Imai et.al., 2001) is represented in a number of other Xenopus maternal mRNAs as well as in mRNA 3’ UTRs of vertebrate species. The early acting MBE is functionally distinct from the late acting cytoplasmic polyadenylation elements (CPEs). The ability of the MBE to direct early translational activation in Xenopus requires interaction with Musashi, a known stem cell self renewal factor (Charlesworth et.al, 2006; Arumugam et.al., 2010). It should be noted that in mammalian somatic cells Musashi appears to facilitate repression of MBE-containing mRNAs, suggesting a context-dependent regulation of Musashi translational control.
::Features
Feature Key MBE
::Transcript(s) / Gene(s)
UTR(s)
Description Species Link Ref.
3' UTR in Xenopus laevis c-mos oncogene (mosxe), mRNA. Xenopus laevis UTRef: 3XLAR009639 [U1]
3'UTR in Xenopus laevis cyclin B5 mRNA Xenopus laevis UTRef: 3XLAR002538
Transcript(s)
Description Species Link Ref.
Xenopus laevis c-mos oncogene (mosxe), mRNA. Xenopus RefSeq: NM_001088094 [T1]
Xenopus laevis cyclin B5 mRNA Xenopus laevis RefSeq: NM_001088519
Gene(s)
Description Species Link Ref.
c-mos oncogene (mosxe). Xenopus laevis EntrezGene: 397924 [G1]
cyclin B5 Xenopus laevis EntrezGene: 398162
::References
ID [1]
Authors Charlesworth, A., Ridge, J., King, L.A., MacNicol, M.C. and MacNicol, A.M.
Title A novel regulatory element determines the timing of Mos mRNA translation during Xenopus oocyte maturation.
Citation EMBO J., 21, 2798-2806.
Year 2002
ID [2]
Authors Charlesworth A, Wilczynska A, Thampi P, Cox LL, MacNicol AM.
Title Musashi regulates the temporal order of mRNA translation during Xenopus oocyte maturation.
Citation EMBO J. 2006 Jun 21; 25(12): 2792-801
Year 2006
ID [3]
Authors Arumugam K, Wang Y, Hardy LL, MacNicol MC, MacNicol AM.
Title Enforcing temporal control of maternal mRNA translation during oocyte cell-cycle progression.
Citation EMBO J. 2010 Jan 20; 29(2): 387-97
Year 2010
ID [4]
Authors Imai T, Tokunaga A, Yoshida T, Hashimoto M, Mikoshiba K, Weinmaster G, Nakafuku M, Okano H.
Title The neural RNA-binding protein Musashi1 translationally regulates mammalian numb gene expression by interacting with its mRNA.
Citation Mol. Cell. Biol. 2001 Jun; 21(12): 3888-900
Year 2001
ID [U1]
Authors Charlesworth, A., Ridge, J., King, L.A., MacNicol, M.C. and MacNicol, A.M.
Title A novel regulatory element determines the timing of Mos mRNA translation during Xenopus oocyte maturation.
Citation EMBO J., 21, 2798-2806.
Year 2002
ID [T1]
Authors Charlesworth, A., Ridge, J., King, L.A., MacNicol, M.C. and MacNicol, A.M.
Title A novel regulatory element determines the timing of Mos mRNA translation during Xenopus oocyte maturation.
Citation EMBO J., 21, 2798-2806.
Year 2002
ID [G1]
Authors Charlesworth, A., Ridge, J., King, L.A., MacNicol, M.C. and MacNicol, A.M.
Title A novel regulatory element determines the timing of Mos mRNA translation during Xenopus oocyte maturation.
Citation EMBO J., 21, 2798-2806.
Year 2002