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::General Information
ID U0035
Creation Date 27 July 2004
Updating Date 27 January 2010
Standard Name Musashi binding element (MBE)
UTRSite Pattern
R UUU[0,2,0] AGU
Random Expectation 0.0118932000 hits/kb
::Taxonomy
UTR Region 3'
Taxon Range Metazoa
::Description
Description During progesterone-stimulated Xenopus oocyte maturation, certain pre-existing (maternal) mRNAs are selectively translated in a strict temporal order. The early translational activation of the Mos mRNA requires a Musashi binding element (MBE) that is located in the Mos 3’ untranslated region (UTR). The MBE lies within a 24 nt region originally termed a polyadenylation response element (PRE), but further analyses demonstrated that the MBE within this sequence was critical for temporal regul......
::Features
Feature Key MBE
::Transcript(s) / Gene(s)
UTR(s)
Description Species Link Ref.
3' UTR in Xenopus laevis c-mos oncogene (mosxe), mRNA. Xenopus laevis UTRef: 3XLAR009639 [U1]
3'UTR in Xenopus laevis cyclin B5 mRNA Xenopus laevis UTRef: 3XLAR002538
Transcript(s)
Description Species Link Ref.
Xenopus laevis c-mos oncogene (mosxe), mRNA. Xenopus RefSeq: NM_001088094 [T1]
Xenopus laevis cyclin B5 mRNA Xenopus laevis RefSeq: NM_001088519
Gene(s)
Description Species Link Ref.
c-mos oncogene (mosxe). Xenopus laevis EntrezGene: 397924 [G1]
cyclin B5 Xenopus laevis EntrezGene: 398162
::References
ID [1]
Authors Charlesworth, A., Ridge, J., King, L.A., MacNicol, M.C. and MacNicol, A.M.
Title A novel regulatory element determines the timing of Mos mRNA translation during Xenopus oocyte maturation.
Citation EMBO J., 21, 2798-2806.
Year 2002
ID [2]
Authors Charlesworth A, Wilczynska A, Thampi P, Cox LL, MacNicol AM.
Title Musashi regulates the temporal order of mRNA translation during Xenopus oocyte maturation.
Citation EMBO J. 2006 Jun 21; 25(12): 2792-801
Year 2006
ID [3]
Authors Arumugam K, Wang Y, Hardy LL, MacNicol MC, MacNicol AM.
Title Enforcing temporal control of maternal mRNA translation during oocyte cell-cycle progression.
Citation EMBO J. 2010 Jan 20; 29(2): 387-97
Year 2010
ID [4]
Authors Imai T, Tokunaga A, Yoshida T, Hashimoto M, Mikoshiba K, Weinmaster G, Nakafuku M, Okano H.
Title The neural RNA-binding protein Musashi1 translationally regulates mammalian numb gene expression by interacting with its mRNA.
Citation Mol. Cell. Biol. 2001 Jun; 21(12): 3888-900
Year 2001
ID [U1]
Authors Charlesworth, A., Ridge, J., King, L.A., MacNicol, M.C. and MacNicol, A.M.
Title A novel regulatory element determines the timing of Mos mRNA translation during Xenopus oocyte maturation.
Citation EMBO J., 21, 2798-2806.
Year 2002
ID [T1]
Authors Charlesworth, A., Ridge, J., King, L.A., MacNicol, M.C. and MacNicol, A.M.
Title A novel regulatory element determines the timing of Mos mRNA translation during Xenopus oocyte maturation.
Citation EMBO J., 21, 2798-2806.
Year 2002
ID [G1]
Authors Charlesworth, A., Ridge, J., King, L.A., MacNicol, M.C. and MacNicol, A.M.
Title A novel regulatory element determines the timing of Mos mRNA translation during Xenopus oocyte maturation.
Citation EMBO J., 21, 2798-2806.
Year 2002